نتایج جستجو برای: pbn
تعداد نتایج: 411 فیلتر نتایج به سال:
Derivatives of artemisinin, a compound extracted from the wormwood Artemisia annua L, have potent anticancer properties. The anticancer mechanisms of artemisinin derivatives have not been fully-elucidated. We hypothesize that the cytotoxicity of these compounds is due to the free radicals formed by interaction of their endoperoxide moiety with intracellular iron in cancer cells. The effects of ...
After a brief discussion of Markov Evolution Formula (MEF) expressed in Probability Bracket Notation (PBN), its close relation with the joint probability distribution (JPD) of Visible Markov Models (VMM) is demonstrated by introducing Markov State Chain Projector (MSCP). The state basis and the observed basis are defined in the Sequential Event Space (SES) of Hidden Markov Models (HMM). The JPD...
Recent evidence suggests that postischemic myocardial dysfunction ("stunning") may be mediated by oxygen free radicals, but the exact time window during which the critical radical-mediated damage develops remains unknown. Furthermore, the evidence for the oxyradical hypothesis is indirect and, therefore, inconclusive. Thus, the potent and cell-permeable antioxidant N-(2-mercaptopropionyl)-glyci...
We give, in terms of (generalized) cyclic types, a criterion for two elements of Tn, PT n, IS(N), Bn, PBn and Cn to be conjugate with respect to the conjugation defined as the transitive closure of the xy ∼ yx relation.
Drug resistant patients undergoing epilepsy surgery have a good chance to become sensitive to anticonvulsant medication, suggesting that the resected brain tissue is responsible for drug resistance. Here, we address the question whether P-glycoprotein (Pgp) and multidrug resistance-associated proteins (MRPs) expressed in the resected tissue contribute to drug resistance in vitro. Effects of ant...
Parabrachial neural coding of taste stimuli in awake rats. J. Neurophysiol. 78: 2254-2268, 1997. In awake, behaving rats, the activity of 74 single neurons in the pontine parabrachial nucleus (PBN) was recorded in response to sapid stimulation by 15 chemicals. Of these, 44 taste cells were tested with all 15 stimuli. Based on their responsiveness to 4 standard stimuli, these neurons were catego...
Boolean networks form a class of disordered dynamical systems that have been studied in physics owing to their relationships with disordered systems in statistical mechanics and in biology as models of genetic regulatory networks. Recently they have been generalized to probabilistic Boolean networks (PBNs) to facilitate the incorporation of uncertainty in the model and to represent cellular con...
Bayes nets (BNs) for relational databases are a major research topic in machine learning and artificial intelligence. When the database exhibits cyclic probabilistic dependencies, measuring the fit of a BN model to relational data with a likelihood function is a challenge [5, 36, 28, 9]. A common approach to difficulties in defining a likelihood function is to employ a pseudo-likelihood; a prom...
Recently, clinical trials of several neurodegenerative diseases have increasingly targeted the evaluation of the effectiveness of various antioxidants. The results so far are encouraging but variable and thus confusing. Rationale for the possible clinical effectiveness of antioxidants in several degenerative conditions has arisen out of the many years of basic science generally showing that rea...
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