PURPOSE Fatty acid synthase (FASN) regulates de novo lipogenesis, body weight, and tumor growth. We examined whether common germline single nucleotide polymorphisms (SNPs) in the FASN gene affect prostate cancer (PCa) risk or PCa-specific mortality and whether these effects vary by body mass index (BMI). METHODS In a prospective nested case-control study of 1,331 white patients with PCa and 1...

OBJECTIVE To detail the distribution of causes of death from localized prostate cancer (PCa). PATIENTS AND METHODS The database PCBase Sweden links the Swedish National Prostate Cancer Register with other nationwide population-based healthcare registers. We selected all 57 187 men diagnosed with localized PCa between 1997 and 2009 and their 114 374 PCa-free control subjects, matched according...

BACKGROUND Interleukin (IL)-35 is a novel inhibitory cytokine and has recently been implicated in tumor immunity. However, the role of IL-35 in prostate cancer (PCa) has not been elucidated. OBJECTIVE To evaluate the role of plasma IL-35 in the diagnosis and prognosis of PCa in Chinese patients undergoing initial prostate biopsy. MATERIALS AND METHODS Using ELISA, plasma IL-35 levels were m...

In this project, we studied PCA based appearance model in visual tracking. We implemented PCA AM module in MTF framework and attempted different ways of formulating PCA. In the experiment sections, we demonstrate the tracking performance of offline PCA when combined with different search methods. PCA + Forward Compositional has shown great tracking accuracy and robustness. It indicates a good p...

A unified framework based on the dynamic principal component analysis (PCA) is proposed for performance monitoring of constrained multi-variable model predictive control (MPC) systems. In the proposed performance monitoring framework, the dynamic PCA based performance benchmark is adopted for performance assessment, while performance diagnosis is carried out using a unified weighted dynamic PCA...

This paper presents a novel feature descriptor termed principal component analysis (PCA)-based Advanced Local Octa-Directional Pattern (ALODP-PCA) for content-based image retrieval. The conventional approaches compare each pixel of an with certain neighboring pixels providing discrete information. proposed in this work utilizes the local intensity all eight directions its neighborhood. octa-dir...

Patient-controlled analgesia (PCA) provides excellent pain control and high stability, thereby minimizing the incidence of adverse effects. However, one of our patients experienced respiratory depression and hypotension within 30 minutes of initiation of PCA therapy. We discovered that machine malfunction caused continuous activation of the PCA button, resulting in a drug overdose. The PCA mach...

Piceatannol (3,3',4,5'-tetrahydroxy-trans-stilbene; PCA) is a naturally occurring metabolite of resveratrol (3,4',5-trihydroxy-trans-stilbene; RV). In this study, we identified additional biochemical targets of PCA in human HL-60 promyelocytic leukemia cells. Incubation with PCA led to a significant proportion of apoptotic cells and caused an arrest in the G2-M phase of the cell cycle. PCA depl...

Normal human monocytes and macrophages. as well as leukemic promyelocytes. generate potent procoagulant activity (PCA) resembling thromboplastin. In the present study only mild PCA was detected in a leukemic promyelocytic cell line (HL-60) and in promyelocytic cells induced to differentiate into neutrophils by dimethylsulfoxide (DMSO). After exposure to 1 2-O-tetradecanoylphorbol1 3-acetate (TP...