African Americans have higher rates of asthma prevalence, morbidity, and mortality in comparison with other racial groups. We sought to characterize endotypes of childhood asthma severity in African American patients in an inner-city pediatric asthma population. Baseline blood neutrophils, blood eosinophils, and 38 serum cytokine levels were measured in a sample of 235 asthmatic children (6-17 ...

Background The acquisition of knowledge by parents of children with asthma plays an important role in the treatment of children. Thus, it is important to understand their needs and provide this information through available methods such as a website.The aim of this studywas to determine the content of a pediatric asthma website based on the evaluation of parents information needs. Materials and...

cutaneous immunotherapy in the treatment of pediatric patients with respiratory allergy. While the results of a large randomized trial of pediatric patients with asthma brought into question the benefit of SCIT, this review reassures clinicians that evidence, ranging from low to high quality, exists to support the treatment of atopic respiratory disease in children. Since environmental avoidanc...

T he ubiquity of non-adherence with medication regimens is well-known to clinicians and has been extensively documented in the literature. Research that has quantified the frequency of pediatric non-adherence across a range of chronic illnesses such as diabetes, rheumatoid arthritis, and cystic fibrosis has found that adherence levels #50% of prescribed dosage are common. Studies of children’s ...

Healthcare big data is being widely touted as a potential resource for curbing costs and improving outcomes. However, numerous challenges remain for leveraging this data to its full potential. In this position paper we identify the difficulties that characterize clinical data, based on our experiences working with pediatric asthma data from Children’s Healthcare of Atlanta. The specific dataset...

OBJECTIVE To identify and describe specific instruments to assess health-related quality of life (HRQoL) in children and adolescents with asthma. DATA SOURCE Searches were performed in the PubMed, Ovid, and LILACS databases using different combinations of key words (MeSH terms), selecting original articles on the development of specific HRQoL questionnaires, published in English, Portuguese, ...

Tulobuterol patches are long-acting bronchodilators for percutaneous absorption including the β(2)-adrenoreceptor agonist tulobuterol, as a main ingredient, used for long-term management of pediatric asthma. Since patients who have pediatric asthma often also have atopic dermatitis in which the skin barrier is impaired, we compared the skin penetration profiles of the brand and generic patches ...

Conclusions Smoking during pregnancy is asthma’s predisposing factor at all ages. Mothers who smoked during pregnancy were three times more likely to acquire children suffering from asthma than those who did not smoke. Authors’ details 2 Pediatric Unit, University of Athens, Athens, Greece. Intensive Care Unit, General Hospital of Kalamata, Kalamata, Greece. Pediatric Unit, General Hospital of ...

Background EIA (Exercise-induced Asthma) can be considered a marker of severity and disease control in asthma. There are several diagnostic tools to evaluate airway hyperresponsiveness in EIA, but it has not been establish the best one. Our objective is to explore bronchial hyperresponsiveness with different lung function measurement techniques among a pediatric population with clinical history...

BACKGROUND Access to medical care and severe pediatric asthma outcomes vary with geography, but the relationship between them has not been studied. OBJECTIVE We sought to evaluate the relationship between geographic access and health outcomes for pediatric asthma. METHODS The severe outcome measures include emergency department (ED) visits and hospitalizations for children with an asthma di...