Ciprofloxacin, a quinolone with good intracellular penetration may possibly be used for treatment of melioidosis caused by Burkholderia pseudomallei, but problems with resistance may be encountered. Amino acid substitutions in gyrA/gyrB have given rise to fluoroquinolone resistance in various microorganisms. Using published primers for gyrA and gyrB, PCR was performed on 11 isolates of B. pseud...

In-situ testing techniques have proven to be successful in improving the speed and reliability of geotechnical investigations. One of the most common in-situ methods in engineering geology and site investigation is Cone Penetration Test (CPT), which is mainly used for characterization of soils, as it is a robust, simple, fast, reliable and economic test that can provide continuous soundings of ...

We consider the nonlinear dynamics of a single vortex in a superconductor in a strong rf magnetic field B0 sin t. Using the London theory, we calculate the dissipated power Q B0 , and the transient time scales of vortex motion. For the linear Bardeen-Stephen viscous drag force, vortex velocities reach unphysically high values during vortex penetration through the oscillating surface barrier. It...

Infections with rapidly evolving pathogens are often treated using combinations of drugs with different mechanisms of action. One of the major goal of combination therapy is to reduce the risk of drug resistance emerging during a patient's treatment. Although this strategy generally has significant benefits over monotherapy, it may also select for multidrug-resistant strains, particularly durin...

Infection with fungal pathogens on wheat varieties with different levels of resistance was tested at ambient (NC, 390 ppm) and elevated (EC, 750 ppm) atmospheric CO2 levels in the phytotron. EC was found to affect many aspects of the plant-pathogen interaction. Infection with most fungal diseases was usually found to be promoted by elevated CO2 level in susceptible varieties. Powdery mildew, le...

Root holoparasitic angiosperms, like Orobanche spp, completely lack chlorophyll and totally depend on their host for their supply of nutrients. O. crenata is a severe constraint to the cultivation of legumes and breeding for resistance remains the most economical, feasible, and environmentally friendly method of control. Due to the lack of resistance in commercial pea cultivars, the use of wild...

The move to the cloud brings a number of new security challenges, but the application remains your last line of defense. Engineers are extremely well poised to perform tasks critical for securing the application—provided that certain key obstacles are overcome. Cloud Shifts the Burden of Security to Development

The Alekseevski-Tate equations have long been used to predict the penetration, penetration velocity, rod velocity, and rod erosion of long-rod projectiles or kinetic-energy penetrators [1]. These nonlinear equations were originally solved numerically, then by the exact analytical solution of Walters and Segletes [2, 3]. However, due to the nonlinear nature of the equations, the penetration was ...

Attack by the host powdery mildew Erysiphe cichoracearum usually results in successful penetration and rapid proliferation of the fungus on Arabidopsis. By contrast, the non-host barley powdery mildew Blumeria graminis f. sp. hordei (Bgh) typically fails to penetrate Arabidopsis epidermal cells. In both instances the plant secretes cell wall appositions or papillae beneath the penetration peg o...