background: there have been some reports about the possible n-methyl-d-aspartate (nmda) antagonist activity of guaifenesin. as drugs with a similar structure to guaifenesin (i.e. felbamate) and those with nmda antagonist activity have been clinically used as anticonvulsants, the aim of this study was to determine whether guaifenesin has an anticonvulsant effect in an animal model of seizure. me...

Experiments using male CD1 mice were carried out to investigate the effects of subchronic (daily administration for 8 days) pretreatments with drugs enhancing GABAergic transmission (diazepam, 10 mg/kg, ip; gabapentin, 100 mg/kg, po; or vigabatrin, 500 mg/kg, po) on pentylenetetrazol (PTZ)-induced seizures, 24 h after the last injection. Subchronic administration of diazepam reduced latencies t...

Salvia verticillata is one of the salvia species which possesses remarkable antioxidant activity. In the present study, we investigated the possible effects of hydro-alcoholic extract from Salvia verticillata plant (SVE) in various models of anxiety, depression and seizure in mice. Mice were randomly divided into control (saline), SVE-treated and standard treatment groups. The SVE-treated group...

THE RAPID turnover of phosphatidate (PhA) and phosphatidyl inositol (PhI) in neural tissue has been related to synaptic function by a number of observations. Increased incorporation of labelled phosphate into these lipids has been reported when cholinergic agents are added to incubated slices of brain (BROSSARD and QUASTEL, 1963; HOKIN and HOKIN, 1955), to homogenates (REDMAN and HOKIN, 1964; D...

To study the functions of 5-HT4 receptors, a null mutation was engineered in the corresponding gene. 5-HT4 receptor knock-out mice displayed normal feeding and motor behaviors in baseline conditions but abnormal feeding and locomotor behavior in response to stress and novelty. Specifically, stress-induced hypophagia and novelty-induced exploratory activity were attenuated in the knock-out mice....

The efficacy of Flunarizine (FLU), a calcium channel blocker, in combination with conventional antiepileptic drugs, phenytoin (PHT), carbamazepine (CBZ), sodium valproate (VPA), and ethosuximide (ESM), at ED50 doses, were examined for protective effects against maximal electroshock seizures (MES) and pentylenetetrazol (PTZ) induced seizures in mice. In both models, only VPA and FLU showed signi...