AIM To investigate the structure of dyspeptic symptoms and determine the association between dyspeptic symptoms and endoscopic findings in patients referred for upper gastrointestinal endoscopy by family physicians in a country with a high prevalence of Helicobacter pylori infection. METHODS Consecutive outpatients (n=172; median 36 years, range 18-75; 85 male; 87 female) were referred to upp...

Gastrocolic fistulas are observed in association with several conditions. Traditionally, peptic ulcer disease was commonly implicated in the formation of gastrocolic fistulas; however, this is now a rare etiology. Here, we present a case of gastrocolic fistula secondary to peptic ulcer disease alone, in addition to reviewing the literature and providing options for diagnosis and treatment.

BACKGROUND/AIMS The connection between Helicobacter pylori and complicated peptic ulcer disease in peptic ulcer bleeding (PUB) patients taking nonsteroidal anti-inflammatory drugs has not been established. In this study, we sought to determine whether delayed H. pylori eradication therapy in PUB patients increases complicated recurrent peptic ulcers. METHODS We identified inpatient PUB patien...

Nonsteroidal anti-inflammatory drugs (NSAIDs) have gastrointestinal side effects such as dyspepsia, peptic ulcer, hemorrhage, and perforation. Misoprostol and PPIs have been used to prevent NSAID-induced gastroduodenal injury. Rebamipide increases gastric mucus and stimulates the production of endogenous prostaglandins. The prophylactic effect of rebamipide on NSAID-induced gastrointestinal com...

A peptic ulcer is an erosion in a segment of the gastro intestinal mucosa, typically in the stomach (gastric ulcer) or first few centimeters of duodenum (duodenal ulcer) that penetrates through the muscularis mucosae. Contrary to popular belief, ulcer is not caused by spicy food but instead is most commonly due to either an infection or long term use of medications. Standard treatment is a comb...

Normally there is a balance between the protective factors (e.g. mucus, bicarbonate, prostaglandins, nitric oxide and normal blood flow) and aggressive factors (e.g. acid plus pepsin, active oxidants, leukotrienes, endothelins, bile or exogenous factors including nonsteroidal anti-inflammatory drugs). Peptic ulcer develops when aggressive factors overcome the protective mechanisms (Borrelli & I...

A perforated peptic ulcer in a child is a rare entity. Severe abdominal pain in an ill-appearing child with a rigid abdomen and possibly with signs of shock is the typical presenting feature of this life-threatening complication of peptic ulcer disease. We present a case of a 14.5-year-old adolescent girl who developed abdominal and shoulder pain that resolved after 1 day. She was then complete...

According to an estimate made by Avery Jones and Pollak (1945), 1,500,000 men and women in England and Wales suffer from peptic ulcer, and Bockus (1943) expressed the general opinion when he said that " Well over 10 per cent. of all adults of the male sex have or have had an ulcer." It is therefore of considerable interest to determine the significance of peptic ulcer to industry, in terms of s...

The Helicobacter pylori iceA gene was recently identified as a genetic marker for the development of peptic ulcer in a Western population. To assess the significance of iceA subtypes of H. pylori in relation to peptic ulcer, 140 Japanese clinical isolates (88 from Fukui and 52 from Okinawa) were characterized. Sequence analysis of the iceA1 gene from 25 representative Japanese strains was also ...

The present paper compares the temporal changes of cigarette consumption with those of peptic ulcer mortality in the United Kingdom. Cumulative cigarette consumption increased in men born between 1845 and 1915 and remained constant or decreased in all subsequent generations. It increased in women born between 1835 and 1955. In contrast, both male and female mortality from gastric and duodenal u...