Perforation is a life-threatening complication of peptic ulcer disease. Smoking and use of non-steroidal anti-inflammatory drugs are important risk factors for perforation. Diagnosis is made clinically and confirmed by the presence of pneumoperitoneum on radiographs. Nonoperative management is successful in patients identified to have a spontaneously sealed perforation proven by water-soluble c...

Hans Selye in a note to Nature in 1936 initiated the field of stress research by showing that rats exposed to nocuous stimuli responded by way of a 'general adaptation syndrome' (GAS). One of the main features of the GAS was the 'formation of acute erosions in the digestive tract, particularly in the stomach, small intestine and appendix'. This provided experimental evidence for the view based ...

Up to 10% of people worldwide are affected by the chronic condition known as Peptic Ulcer. Ulcer development is influenced pH gastric juice and a decline in mucosal defences. The main factors affecting resistance damage Helicobacter pylori (H. pylori) infection non-steroidal anti-inflammatory medicines (NSAIDs). Treatment for Ulcers today challenging task every patient. A digestive disorder tha...

An antiulcer polysaccharide fraction (BR-2) from Bupleurum falcatum L. was examined for its effect on the healing of chronic ulcers induced by acetic acid in rats. When BR-2 was administered orally to the rats, it was shown to be effective in the healing of acetic acid-induced chronic ulcer. This result suggests that the use of herbal prescriptions containing B. falcatum L. may prove useful for...

BACKGROUND Proton pump inhibitors (PPIs) decrease the rate of rebleeding following endoscopic hemostatic therapy in patients with bleeding peptic ulcers. This study compares the efficacy of oral omeprazole vs intravenous pantoprazole in decrease of rebleeding of peptic ulcer patients. METHODS One hundred and six patients with high risk peptic ulcer were randomized to receive either oral omepr...

Perforations of peptic ulcers account for between 5 % and 8% of abdominal conditions submitted to urgent laparotomy. The general practitioner may see less than one case a year even though in an average-sized practice he has many patients with peptic ulcers. This relative rarity of the complication of perforation in the experience of the individual practitioner does not often lead to difficulty ...

The characteristics of patients and the endoscopic features of 196 patients with bleeding peptic ulcer in a multi-ethnic population were investigated. There was a male preponderance (M: F= 6.3: 1) and their mean age was 63.5 years. The prevalence of peptic ulcer bleeding in the Malays and Indians was similar to the ethnic distribution of population. However, the Chinese were over represented. N...