introduction:  on  the  basis  of  percent  depth  dose  (pdd)  calculation,  the  application  of  dosimetry  in  radiotherapy  has  an  important  role  to  play  in  reducing  the  chance  of  tumor  recurrence. the aim of this study is to introduce a new formula for calculating the centeral axis  percent depth doses of cobalt-60 beam.   materials and methods: in the present study, based on ...

The present study compared the dosimetry of intensity-modulated radiation therapy (IMRT) and three-dimensional conformal radiation therapy (3D-CRT) techniques in patients treated for high-grade glioma. A total of 20 patients underwent computed tomography treatment planning in conjunction with magnetic resonance imaging fusion. Prescription dose and normal-tissue constraints were identical for t...

The myocardial uptake of 125I- and 131I-antimyosin monoclonal antibody Fab in experimental myocarditis in BALB/c mice induced by encephalomyocarditis virus was studied. The biodistribution of 125I-antimyosin demonstrated that the highest ratio of radioactivity appears in the heart of infected mice on day 14 (the ratio of percent dose per gram for the organ to percent dose per milliliter for blo...

Temporal variations in the renal toxicity of aminoglycosides have been reported for experimental animals as well as for humans. In fact, maximal renal toxicity of aminoglycosides was observed when the drug was given during the rest period, while a lower toxicity was observed when the drug was injected during the activity period. The aim of the present study was to evaluate temporal variations i...

introduction: bombesin is a 14-aminoacid peptide isolated from frog skin. the mammalian counterparts of the frog peptide are neuromedin b (nmb) and gastrin-releasing peptide (grp). bombesin (bbn) is a peptide showing high affinity for the gastrin releasing peptide receptor (grpr). prostate, small cell lung cancer, breast, gastric, and colon cancers are known to over express receptors to bombesi...

1. Quiescent sciatic nerve of the frog discharges CO(2) at the average rate of 0.00876 mg. CO(2) per gram of nerve per minute. 2. Sciatic nerve steeped one minute in boiling water discharges CO(2) at first at a low rate and after an hour and a half not at all. 3. Degenerated sciatic nerve discharges CO(2) at a slightly higher rate than normal living nerve does. 4. Connective tissue from the fro...

We compared light-induced fluorescence (LIF) to nominal injected drug dose for predicting the depth of necrosis response to photodynamic therapy (PDT) in a murine tumor model. Mice were implanted with radiation-induced fibrosarcoma (RIF) and were injected with 0, 5, or 10 mg/kg Photofrin. 630-nm light (30 J/cm(2), 75 mW/cm(2)) was delivered to the tumor after 24 hours. Fluorescence emission (la...

A granuloma pouch was formed on the back of rats by the original method of SELYE. Seven days when granuloma tissue reached its maximum, 35S labeled ChS, 59Fe labeled ChS-Fe, labeled ferric ammoninum citrate and colloidal 198Au were injected into the pouch and their absorption and organ distribution examined and compared with the results in the case where 59Fe labeled ferric ammoninum citrate an...

Type 2 diabetes is characterized by progressive beta-cell failure. Indications for exogenous insulin therapy in patients with this condition include acute illness or surgery, pregnancy, glucose toxicity, contraindications to or failure to achieve goals with oral antidiabetic medications, and a need for flexible therapy. Augmentation therapy with basal insulin is useful if some beta-cell functio...

INTRODUCTION (125)I-Meta-iodobenzylguanidine (MIBG) cardiac uptake is reduced in mice with 1-methyl-4-phenyl-1,2,3,6-tetrahydroxypyridine (MPTP)-induced parkinsonism, although the cause of disturbance of norepinephrine (NE) turnover is unclear. METHODS C57BL6 mice (15 weeks old) were divided into six groups (n=14 each) according to the timing of MPTP injection (40 mg/kg) before (125)I-MIBG: G...