BACKGROUND The function of the peripheral microvascular may be interrogated by measuring perfusion, tissue oxygen concentration, or venous oxygen saturation (SvO2) recovery dynamics following induced ischemia. The purpose of this work is to develop and evaluate a magnetic resonance (MR) technique for simultaneous measurement of perfusion, SvO2, and skeletal muscle T2*. METHODS Perfusion, Intr...

INTRODUCTION: Respiratory motion of the heart represents a major practical problem in myocardial perfusion MRI. Firstly, the tracer kinetic models used for quantifying perfusion require that the myocardium remains stationary throughout the image time series, thus mandating a prior registration of the images. Secondly, modern k-space undersampling techniques, such as k-t BLAST [1] and UNFOLD [2]...

Methods In this substudy of the NOMI-trial (ClinicalTrials.gov identifier: NCT01398384), quantitative perfusion analysis was compared between patients that underwent an MR first pass perfusion sequence with a shared (n=25) and a non-shared prepulse (n=25), at 4 months after revascularized myocardial infarction. Perfusion imaging consisted of 3 short-axis slices acquired every heartbeat, with a ...

Assessing myocardial perfusion using Rb-PET is emerging as a valuable clinical tool. The rapid decay (T = 76 s) allows for absolute quantification of both rest and stress perfusion within 30 minutes. In addition to evaluation of epicardial disease with perfusion defects, also evaluation of balanced coronary and small vessel disease is possible. For further evaluation of how Rb-PET can be used c...

Background Dynamic contrast enhanced cardiovascular magnetic resonance imaging (DCE-CMR) allows for high-resolution analysis of myocardial perfusion by preserving important spatial information. However high resolution perfusion quantification suffers from the poor signal-to-noise ratio (SNR) of voxel-based data. Previously spatial averaging (segmental or sub-segmental analysis) has been used to...

Dynamic perfusion magnetic resonance (MR) imaging is a commonly used imaging technique that allows to measure the tissue perfusion in an organ of interest via assessment of various hemodynamic parameters such as blood flow, blood volume, and mean transit time. In this paper, we tackle the problem of recovering perfusion MR images from undersampled k-space data. We propose a novel reconstruction...

The effect of irreproducible bulk tissue motions upon quantification of tissue perfusion and diffusion was studied via computer simulation of random phase error in conventional phase-encoded perfusion /diffusion MRI. Simulations using acquisition parameters typical for human brain studies demonstrate that bulk motion irreproducibility of -60 pm/s can produce phase instability on the order of 20...

BACKGROUND AND PURPOSE Color-coded perfusion maps can be calculated from ultrasound harmonic gray-scale imaging data to analyze brain tissue perfusion. METHODS In 13 healthy volunteers, 2 doses (0.5 and 1.5 mL) of Optison, a perfluoropropane-containing ultrasound contrast agent, were injected intravenously, and they produced a strong increase in echo enhancement in the brain parenchyma. The c...

Cardiovascular magnetic resonance (CMR) imaging has emerged as an important research tool for studies of ischemic heart disease due to its versatility, relatively low cost, and high image quality that allows accurate and reproducible quantification of cardiac structure and function. However, while imaging of cardiac function and myocardial viability (and to some extend imaging of the coronary a...

The value of perfusion scintigraphy in the detection of pulmonary embolism (PE) was demonstrated as early as 1964 by Wagner et al. PE causes perfusion defects that conform to the anatomical distribution of the pulmonary vascular bed. Perfusion defects in acute PE are therefore of sub-segmental, segmental or lobar character. Ventilation is normally preserved in these areas and the observed wedge...