Recent electrophysiological evaluations, performed by pattern electroretinogram (PERG) and visual evoked potential (VEP) recordings, suggest that patients affected by open angle glaucoma (OAG) present a ret-inal dysfunction and a delay in neural conduction in the postretinal visual pathways (Parisi 1997). Although an impairment of the innermost retinal layers (ganglion cells and their fibres) i...

Electroretinography, a technique that objectively assesses the function of the retina, is used to evaluate the progression of retinal disorders. Part I of this two-part presentation discussed the morphologic and physiologic characteristics of the retina. The information presented in Part II can help practitioners determine when an electroretinogram (ERG) is recommended. In addition to the stand...

The slow progression of diabetic retinopathy makes it difficult to assess the effects of intervention therapy. There is thus a need for surrogate markers of visual change in diabetes. Colour vision tests and electroretinography (ERG) may be useful in this regard; yet little is known of their relative performance in the assessment of visual dysfunction in diabetes. The aim of the present study w...

A typical finding in dominant infantile optic atrophy (DIOA) is the variation of the phenotypic expression of the DIOA gene even within one family. It is of special interest for genetic consultation to evaluate an examination method for detecting subclinically involved patients. Seven patients of two families were examined. Three of them had the typical symptoms of DIOA: reduced visual acuity, ...

Silent substitution and selective adaptation techniques were used to obtain full field S-cone and L + M-cone electroretinograms from 18 patients with ocular hypertension (OHT), 9 with normotensive glaucoma (NTG), 18 with early primary open angle glaucoma (POAG) and 19 normal controls. Pattern electroretinograms were also recorded, using a reduced check size to increase the contribution of retin...

POAG: Primary Open Angle Glaucoma; IOP: Intra-Ocular Pressure; APP: Amyloid Precursor Protein, RGCs: Retinal Ganglion Cells; CSF: Cerebro-Spinal Fluid; APOE: Apolipoprotein E; AD: Alzheimer’s Disease; EGS: European Glaucoma Society; RNFL: Retinal Nerve Fiber Layer; GON: Glaucomatous Optic Neuropathy; PD: Parkinson’s Disease; NMDA: N-Methyl D-Aspartate; BDNF: Brain-Derived Neurotrophic Factor; E...

The University of Maryland Physics Education Research Group (UMd-PERG) carried out a five-year research project to rethink, observe, and reform introductory algebra-based (college) physics. This class is one of the Maryland Physics Department’s large service courses, serving primarily life-science majors. After consultation with biologists, we re-focused the class on helping the students learn ...

We generalize exactness to games with non-transferable utility (NTU). In an exact game for each coalition there is a core allocation on the boundary of its payoff set. Convex games with transferable utility are well-known to be exact. We study five generalizations of convexity in the NTU setting. We show that each of ordinal, coalition merge, individual merge and marginal convexity can be unifi...

PURPOSE To investigate whether postmenopausal hormone therapy (HT) increases retinal and ONH blood flow (BF) and protects ONH topography and the function of retinal ganglion cells in postmenopausal women (PMW). The effect of estradiol (E(2)) treatment on retinal tissue perfusion was also investigated in ovariectomized rats, an animal model for menopause. METHODS Sixty-four healthy PMW were re...

Increasing anatomical evidence indicates that large retinal ganglion cells (M-cells) are preferentially damaged in primary open angle glaucoma (OAG), while the smaller ganglion cells (P-cells) are relatively spared. In 13 patients with defined OAG and modest visual field defects, we evaluated the responses to stimuli that are expected to involve primarily the function of the P-pathway and compa...