Introduction: Crohn's disease is an idiopathic inflammatory disorder of unknown etiology, associated with genetic, immunological, and environmental factors. The incidence this continues to rise in developed countries. In almost 25% patients, perianal fistulas occur during the course disease, which are difficult treat significantly impair patient's quality life.
 Aim study: To summarize cur...

PURPOSE The traditional treatment of a complex high fistula-in-ano by internal sphincterotomy and insertion of a cutting seton carries a risk of fecal incontinence. We have assessed the functional impact of treating patients with a complex fistula-in-ano by a cutting seton fistulotomy technique that preserves the internal sphincter. METHODS The operative steps consisted of initial eradication...

Anal malignancies constitute approximately 1 to 3 % of all large-bowel carcinomas 1, 2 and less than 6 % of all anorectal carcinomas 3,4 . The latter is either squamous or glandular type. The squamous cell carcinoma is much more common than adenocarcinoma. Anal canal adenocarcinoma is subclassified into adenocarcinoma arising in anal mucosa and extamucosal (perianal) adenocarcinoma. The latter ...

OBJECTIVE Lack of standardised outcomes hampers effective analysis and comparison of data when comparing treatments in fistulising perianal Crohn's disease (pCD). Development of a standardised set of outcomes would resolve these issues. This study provides the definitive core outcome set (COS) for fistulising pCD. DESIGN Candidate outcomes were generated through a systematic review and patien...

INTRODUCTION Management of perianal abscesses has remained largely unchanged for over 50 years. The evidence for postoperative wound packing is limited and may expose patients to painful procedures with no clinical benefit and at considerable increased cost. METHODS Patients were recruited in 15 UK centres between December 2013 and October 2014. Outcome measures included number of dressing (p...