Ovarian cancer, a term that encompasses ovarian, fallopian, and peritoneal cancers, is the leading cause of gynecologic cancer mortality. To improve patient outcomes, the field is currently focused on defining the mechanisms of cancer formation and spread, early diagnosis and prevention, and developing novel therapeutic options. This review summarizes recent advances in these areas. Referee Sta...

Disseminated peritoneal leiomyomatosis (DPL) is a very rare condition that almost always occurs in young women subjected to an altered hormonal milieu, usually pregnancy. To the surgeon, DPL may appear as metastases; the possibility of DPL should be considered whenever peritoneal nodules are encountered in a young woman, particularly if she is pregnant. Here we present the case report of a 35-y...

Introduction: Detection of malignant cells in the peritoneal cavity indicates the extension of cancer cells. The aim of this study is to evaluate the incidence rate of positive cytology in colorectal cancer and its relationship with the local progress of the tumor.  Methods: In a 2-year prospective study in Mashhad and Iran Universities of Medical Sciences, peritoneal lavage was performed on...

Ovarian fibrothecoma is a rare, benign neoplasm of the sex cords and stroma ovary. Patients may present with abdominal pelvic pain / or distension, sometimes postmenopausal bleeding. Large tumors (> 10cm) are often associated pleural peritoneal effusion mimicking an advanced ovarian malignancy (Deimon –Meigs syndrome). We report 2 cases giant ascites pleurisy. Both patients were postmenopa...

Abstract Background Primary appendiceal tumours are rare. Our experience with the incidental primary and their histological diversity. Patients Method Operative pathological databases of appendicectomies for presumed diagnosis acute appendicitis between January 2015 December 2020 were interrogated. Clinicopathological data collected analysed to present incidence tumours, histopathological diver...

Ovarian cancer is usually diagnosed at an advanced stage, rendering the possibility of cure unlikely. To date, no cost-effective screening test has proven effective for reducing mortality. To estimate the window of opportunity for ovarian cancer screening, we develop a branching process model for ovarian cancer growth and progression accounting for three cell populations: Primary (cells in the ...

In the earliest days of the modern chemotherapeutic era (1950s), it was recognized that the direct delivery of cytotoxic agents into the peritoneal cavity had the potential to be a clinically useful approach in the treatment of malignancies principally confined to this body compartment.[3,4] However, it was only with the publication of a pharmacokinetic modeling study by Dedrick et al in the la...

Owing to its peculiar pharmacological characteristics, paclitaxel attains substantial intra-peritoneal concentration for a prolonged period when delivered intra-peritoneally, and is active against peritoneal metastasis of ovarian cancer. It is also considered promising against disseminated gastric cancer. However, the fact that the intra-peritoneal paclitaxel has not been approved in Japan has ...

BACKGROUND This study was performed to assess the impact of irradiation on the tissue penetration depth of doxorubicin delivered during Pressurized Intra-Peritoneal Aerosol Chemotherapy (PIPAC). METHODS Fresh post mortem swine peritoneum was cut into 10 proportional sections. Except for 2 control samples, all received irradiation with 1, 2, 7 and 14 Gy, respectively. Four samples received PIP...