BACKGROUND AND PURPOSE Chronic pain is often a symptom of knee osteoarthritis (OA) for which current analgesics are either inadequate or are associated with serious side effects. The endocannabinoid system may offer alternative targets for pain relief. We evaluated the effects of a potent and selective monoacylglycerol (MAG) lipase inhibitor (MJN110) on OA pain behaviour, spinal mechanisms of a...

The inner ear was previously assumed to be an "immune-privileged" organ due to the existence of its tight junction-based blood-labyrinth barrier. However, studies performed during the past decade revealed that the mesenchymal region of the cochlea, including its lateral wall, is a common site of inflammation. Neutrophils do not enter this region, which is consistent with the old dogma; however,...

Glioblastoma multiforme (GBM) is one of the most aggressive malignant brain tumors and urgently requires development new therapeutic strategies. In this study, an innovative hybrid in vitro vascularized GBM-on-a-chip model presented as a strategic integration microfluidics 3D bioprinting technologies. The system can recreate compartmentalized tumor microenvironment, comprising functional blood ...

OBJECTIVES We describe the morphologic and immunohistochemical features of 17 endometrial stromal neoplasms, 16 sarcomas, and one stromal nodule. METHODS We reviewed 35 cases interpreted as endometrial stromal neoplasms, but 17 high-grade endometrial stromal sarcomas (ESS) and one case of mixed endometrial sarcoma and leiomyosarcoma were excluded from the study. Data from the Surveillance Epi...

Epithelioid angiomyolipoma (EAML) of the kidney is an uncommon neoplasm with malignant potential. It can occur sporadically or be associated tuberous sclerosis. EAML a monotypic variant (AML), which classified as perivascular epithelioid cell tumor. Due to its nature and paucity fat components, unlike classic AML, has abundant adipose tissue characteristic features on CT scans, it difficult dis...

Central neurocytomas are uncommon tumors of the CNS, representing approximately 0.1-0.5% of all primary CNS tumors. Patients most often present with symptoms of increased intracranial pressure (headache, nausea/vomiting, diplopia) due to obstructive hydrocephalus. Rarely, central neurocytomas may present with a hemorrhage. Central neurocytomas are intraventricular tumors with a predilection for...