In 1946 Hale described a method for demonstrating acid mucopolysaccharides in sections based on the affinity of these compounds for colloidal iron oxide in acid solution. The combined iron was demonstrated by conversion to prussian blue. It has been found that bacterial capsules and slime are very well stained by Hale's method. This is possibly due to their content of acid mucopolysaccharides, ...

INTRODUCTION Rheumatoid arthritis (RA) is a chronic disease causing recurring inflammatory joint attacks. These attacks are characterized by macrophage infiltration contributing to joint destruction. Studies have shown that RA treatment efficacy is correlated to synovial macrophage number. The aim of this study was to experimentally validate the use of in vivo superparamagnetic iron oxide nanop...

Monitoring the evolution of potassium carriers during charge/discharge Prussian blue batteries by operando K-edge X-ray absorption spectroscopy.

Introduction Transplantation of embryonic stem cell derivatives is a promising therapeutic approach for heart failure. Current methods of studying stem cell engraftment rely heavily on postmortem histological sampling. This precludes longitudinal monitoring and hinders studies of biodistribution, survival and proliferation. Noninvasive MR imaging of grafted cells is possible through cell labeli...

Introduction: Glioblastoma multiform is the most common malignant brain tumor, with an invasive nature. Despite the development of conventional therapies such as surgery, radiotherapy and chemotherapy, because of high recurrence rates, the prognosis remains very poor. Over the last decade, nanotechnology has represented an innovative method as nanoparticle-based drug delivery ...

Background & Aims: In spite of frequent produce and use of magnetic nanoparticles in biological fields, there are few studies on their side effects, especially under in-vivo conditions. Method: In this research, the effect of the single-dose intraperitoneal injection of DMSA (dimercaptosuccinic acid) coated magnetic iron oxide nanoparticles (Fe3O4) in different doses (50, 100, 200 and 300 mg/kg...

A disrupted balance of reduced glutathione (GSH) and iron (Fe) and subsequent enhanced susceptibility of lysosomes of lung macrophages (LMs) to oxidants may play a role in lung fibrogenesis. We assessed cellular Fe/GSH, lysosomal membrane permeabilization (LMP), and cell death in cultures of oxidant exposed LMs. LMs from 7 lung fibrosis patients and healthy subjects were exposed to a physiologi...

Currently, effective and specific diagnostic imaging of brain glioma is a major challenge. Nanomedicine plays an essential role by delivering the contrast agent in a targeted manner to specific tumor cells, leading to improvement in accurate diagnosis by good visualization and specific demonstration of tumor cells. This study investigated the preparation and characterization of a targeted MR co...