Rapidly proliferating cells promote glycolysis in aerobic conditions, to increase growth rate. Expression of specific glycolytic enzymes, namely pyruvate kinase M2 and hexokinase 2, concurs to this metabolic adaptation, as their kinetics and intracellular localization favour biosynthetic processes required for cell proliferation. Intracellular factors regulating their selective expression remai...

Biotransformation, the structural modification of chemical compounds, has proved to be an indispensable tool in providing beneficial health effects. Although benefits biotransformation using plant sources been widely studied, anti-adipogenic effect biotransformed dairy products, such as whey, have not yet demonstrated. Here, we investigated whey by Weissella cibaria 3T3-L1 adipocytes. cibaria-b...

UNLABELLED The aim of this study was to clarify whether common single nucleotide polymorphisms (SNPs) of the Peroxisome Proliferator-Activated Receptor-γ (PPAR-γ) gene (rs1801282) and the Peroxisome Proliferator-Activated Receptor-γ Coactivator-1 (PGC-1α) gene (rs8192673) are associated with obesity indexes (BMI, waist circumference) in subjects with type 2 diabetes mellitus (T2DM) in Caucasian...

objective(s): herbal medicines are promising cancer preventive candidates. it has been shown that punica granatum l. could inhibit angiogenesis and tumor invasion. in this study, we investigated whether the anti-angiogenic effect of pomegranate peel extract (ppe) is partly attributable to peroxisome proliferator-activated receptors (ppars) activation in the human umbilical vein endothelial cell...

Submit Manuscript | http://medcraveonline.com J Nutr Health Food Eng 2015, 3(1): 00101 Abbreviations: UCP: Uncoupling Proteins; PGC1-α: Peroxisome Proliferator-Activated Receptor Gamma Co-Activator 1 Alpha; PPARα; Peroxisome Proliferator-Activated Receptor Alpha; BAIBA: β-Aminoisobutyric Acid; ROS: Reactive Oxygen Species; FFA: Free Fatty Acids; ETC: Electron Transport Chain; ATP: Adenosine Tri...

BACKGROUND Systemic therapeutics targeting the peroxisome proliferator-activated receptors have been found to be beneficial in the treatment of diabetic retinopathy. In this paper, we provide a rationale for the use of these therapeutics as intraocular agents. In addition, we introduce the peroxisome proliferator-activated receptors and describe their functions in response to the drugs. DISCU...

BACKGROUND AND AIMS Similar clinical and pathological features have been observed in Alzheimer's disease (AD) and Parkinson's disease with dementia (PDD). Both the peroxisome proliferator-activated receptor-γ (PPAR-γ) gene and the peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) gene are candidates modifying the risk for both diseases. The aim of this study was to clarify wh...

more than 10 million people worldwide are living with parkinson’s disease (pd). the ages of people who have parkinson are variable, usually between 50 and 80 years, the average of them is 55 years old. the symptoms of pd are progressive, and within 10 to 20. it happens when dopaminergic neurons were being degenerate. peripheral and central inflammatory and oxidative stress pathways play a compl...