BACKGROUND AND AIMS Measurement of 7 alpha-hydroxy-4-cholesten-3-one (C4) in serum is a semiquantitative test for bile acid malabsorption (BAM). We have previously established pediatric normal values for C4 with an upper limit of normal of 66.5 ng/mL, independent of age and sex. Here we performed the C4 test in 58 pediatric patients with Crohn's disease (CD) and ulcerative colitis (UC). METHO...

Prolonged diarrhea is usually defined as acute-onset diarrhea lasting 7 days or more, but less than 14 days. Its trend has been declining in recent years because of improvement in the management of acute diarrhea, which represents the ideal strategy to prevent prolonged diarrhea. The pathogenesis of prolonged diarrhea is multifactorial and essentially based on persistent mucosal damage due to s...

Enteropathogenic Escherichia coli (EPEC) is the most important cause of persistent diarrhea in children, particularly in developing countries. Animals serve as pathogenic E. coli reservoirs, and compelling evidence for cross-species EPEC transmission exists. In this report, enzootic EPEC infection associated with up to 10.5% diarrhea-associated morbidity in a large laboratory Dutch Belted rabbi...

device. Introduction In 2002, diarrhea was ranked as the seventh leading cause of death in the world. (1) Estimates from the World Health Organization (WHO) 2000–2003 report show that worldwide, diarrhea accounts for 18% of deaths in children younger than the age of 5 years. (2) Diarrhea commonly is defined as loose or liquid stools that are passed frequently. (3) Although diarrhea acts as a de...

OBJECTIVES Recurring diarrhea and persistent diarrhea are commonly associated with malnutrition and long-term functional deficits. A beneficial approach would be to develop an alanyl-glutamine (AlaGln)-based oral rehydration and nutrition therapy (ORNT). We investigated the effect of an AlaGln-ORNT solution on electrolyte and water absorption in a rat model of secretory diarrhea induced by chol...

This article is devoted to the issue of rotavirus infection in pediatric population and demonstrates worldwide prevalence among causes viral gastroenteritis its persistent leadership fatal diarrhea children first 5 years life. Specific prevention has been actively carried out around world since 2005. Nowadays, we have adequate experience use various vaccines bolstered by their implementation im...

BACKGROUND Persistent and heavy rainfall in the upper and middle Huaihe River of China brought about severe floods during the end of June and July 2007. However, there has been no assessment on the association between the floods and infectious diarrhea. This study aimed to quantify the impact of the floods in 2007 on the burden of disease due to infectious diarrhea in northwest of Anhui Provinc...