Several protein conformational disorders (Parkinson and prion diseases) are linked to aberrant folding of proteins into prefibrillar oligomers and amyloid fibrils. Although prefibrillar oligomers are more toxic than their fibrillar counterparts, it is difficult to decouple the origin of their dissimilar toxicity because oligomers and fibrils differ both in terms of structure and size. Here we r...

New π-conjugated oligomers with high crystallinity were prepared from the simple solvothermal reaction of squaric acid and diaminopyrenes. The oligomers were bonded at the 1,3- and 1,6-positions of the pyrene units, oligo(sq-alt-1,3py) and oligo(sq-alt-1,6py), which greatly affected their planar configuration and resulting mechanochromic properties. Oligomers containing a charge transfer (CT) c...

The synthesis of two poly(p-phenylenevinylene) oligomers (oPPV) laterally substituted by phthalocyanines (Pc) is described. The preparation of Pc-based oligomers and was accomplished by means of Knoevenagel and Wadsworth-Horner-Emmons reactions, respectively. Diformylphthalocyanine was employed as a monomer in these reactions, thus providing functionalised conjugated oligomers upon reaction wit...

The chiroptical properties of an asymmetric poly(diphenylacetylene) are related to the degree polymerization, being opposite for polymers and oligomers.

Oligomers comprising four or sixteen phenylalanine residues with regularly intercalated aliphatic chains of different lengths prepared by solid-phase synthesis exhibit sufficient thermal stability to be used as interfacial agents and processed for the preparation poly(propylene-co-ethylene)-based composite materials. The investigation their adsorption on Kevlar fibers SEM is difficult due surfa...

eethylene polymerization catalysts became available in an enormous variety. the challenge in this research is to find catalysts that are able to connect ethylene molecules in such a way that not only linear chains are produced but variations like branched materials that possess very interesting mechanical properties like linear low density polyethylene (lldpe). in this contribution, three diffe...

Membrane permeability to ions and small molecules is believed to be a critical step in the pathology of Alzheimer's disease (AD). Interactions of oligomers formed by amyloid-β (Aβ) peptides with the plasma cell membrane are believed to play a fundamental role in the processes leading to membrane permeability. Among the family of Aβs, pyroglutamate (pE)-modified Aβ peptides constitute the most a...

'Stacking hybridization reactions' wherein two or more short DNA oligomers hybridize in a contiguous tandem orientation onto a longer complementary DNA single strand have been employed to enhance a variety of analytical oligonucleotide hybridization schemes. If the short oligomers anneal in perfect head-to-tail register the resulting duplex contains a nick at every boundary between hybridized o...