pH is one of the most fundamental parameters describing quality an aqueous solution. We developed a ratiometric fluorescent platform to monitor not only in solution but also on surfaces: our nanoprobe based nanoparticles (FNPs) with red-emitting BODIPY core and pH-sensitive fluorescein derivative grafted outer shell. demonstrated that limited controlled Förster resonance energy transfer occurs ...

The application of poly(lactic acid) for sustained protein delivery is restricted by the harsh pH inside carriers. In this study, we synthesized a pH-responsive comb-shaped block copolymer, polyethylene glycol monomethyl ether-ε-polylysine-g-poly (lactic acid) (PEP)to deliver protein (bovine serum albumin (BSA)). The PEP nanoparticles could automatically adjust the internal pH to a milder level...

We report a pH-responsive gold nanoparticles-in-liposome hybrid nanostructure, which effectively combines the pH-responsive assembly and surface plasmon property changes of 'smart' gold nanoparticles and enhanced systemic circulation and tumor accumulation of the PEG-grafted liposomes.

The acidic extracellular environment of tumors potentiates their aggressiveness and metastasis, but few methods exist to selectively modulate the extracellular pH (pHe) environment of tumors. Transient flushing of biological systems with alkaline fluids or proton pump inhibitors is impractical and nonselective. Here we report a nanoparticles-based strategy to intentionally modulate the pHe in t...

Using dissipative particle dynamics (DPD), we model the interfacial adsorption of pH-responsive polyelectrolytes and polyelectrolyte-grafted nanoparticles (PNPs) at a planar water-oil interface. The electrostatic interactions in the presence of the dielectric discontinuity across the interface are modeled by exploiting the Groot method, which uses an iterative method to solve the Poisson equati...

BACKGROUND Naturally occurring nanoparticles isolated from English ivy (Hedera helix) have previously been proposed as an alternative to metallic nanoparticles as sunscreen fillers due to their effective UV extinction property, low toxicity and potential biodegradability. METHODS This study focused on analyzing the physicochemical properties of the ivy nanoparticles, specifically, those param...

Polyacrylic acid functionalized Fe3O4 nanoparticles (PAA-MNPs) of average size of 10 nm are prepared by a simple soft chemical approach. These PAA-MNPs are conjugated with folic acid through peptide bonding between the carboxylic group on the surface of PAA-MNPs and the amine group of folic acid. The good colloidal stability of FA conjugated MNPs makes it a promising candidate for targeted drug...

a simple and sensitive, solid-phase extraction method for the removal of citalopram drug from waste water has been developed by using magnetic nanoparticles modified with surfactant sodium dodecyl sulfate. these magnetic nanoparticles have shown great adsorptive tendency towards citalopram drug. the effect of different parameters influencing the extraction efficiency of this drug were investiga...

Poly(N-isopropylacrylarnide-CO-methacrylic acid) P(NIPArn/MAA) nanoparticles were investigated as potentiai targetable systems for intravenous drug delivery. The responsive properties of P(NIPAm/MAA) nanoparticles have been characterized using dynamic light scattering (DLS) and responsive adhesion techniques. The hydrodynamic diameter of the nanoparticles decreased with increasing temperature o...