introduction: gamma knife is an instrument specially designed for treating brain disorders. in gamma knife, there are 201 narrow beams of cobalt-60 sources that intersect at an isocenter point to treat brain tumors. the tumor is placed at the isocenter and is treated by the emitted gamma rays. therefore, there is a high dose at this point and a low dose is delivered to the normal tissue surroun...

We have generalized the spectral factor analysis and the factor analysis of dynamic sequences (FADS) in SPECT imaging to a five-dimensional general factor analysis model (5D-GFA), where the five dimensions are the three spatial dimensions, photon energy, and time. The generalized model yields a significant advantage in terms of the ratio of the number of equations to that of unknowns in the fac...

A convolution-based calibration procedure has been developed to use an amorphous silicon flat-panel electronic portal imaging device (EPID) for accurate dosimetric verification of intensity-modulated radiotherapy (IMRT) treatments. Raw EPID images were deconvolved to accurate, high-resolution 2-D distributions of primary fluence using a scatter kernel composed of two elements: a Monte Carlo gen...

The work here presented analyzes the performances (in terms of scatter fraction, spatial resolution, sensitivity, image quality) obtained from a 10detectors small-animal PET, simulated via Geant4 Application for Emission Tomography (GATE), in comparison with other designs studied in previous works. Particular attention is given to the comparison with the 12-detectors miniPET II, already built a...

OBJECT Where no society-based or manufacturer guidance on radiation limits to neuromodulation devices is available, this research provides the groundwork for neurosurgeons and radiation oncologists who rely on the computerized treatment plan clinically for cancer patients. The focus of the article is to characterize radiation parameters of attenuation and scatter when an incident therapeutic x-...

Four methodologies were evaluated for quantifying kilovoltage cone-beam computed tomography (CBCT) dose: the Cone-Beam Dose Index (CBDI), IAEA Report 5 recommended methodology (IAEA), the AAPM Task Group 111 methodology (TG111), and the current dose metric; the Computed Tomography Dose Index (CTDI) on two commercial Varian cone-beam CT imaging systems; the Clinac iX On-Board Imager (OBI); and t...

An efficient reconstruction method for myocardial perfusion single-photon emission computed tomography (SPECT) has been developed which compensates simultaneously for attenuation, scatter, and resolution variation. The scattered photons in the primary-energy-window measurements are approximately removed by subtracting the weighted scatter-energy-window samples. The resolution variation is corre...

Introduction: Important complications of venous thromboembolism (VTE) are a longer hospital stay, readmission, recurrence of the emboli, complications of anticoagulant therapy and death in a sever condition. In present study, the volume measurement accuracy of the medical imaging interaction toolkit (MITK) software on determining VTE in computed tomography images was evaluated....

A fast algorithm is constructed to facilitate dose calculation for a large number of randomly sampled treatment scenarios, each representing a possible realisation of a full treatment with geometric, fraction specific displacements for an arbitrary number of fractions. The algorithm is applied to construct a dose volume coverage probability map (DVCM) based on dose calculated for several hundre...