The pharmaceutical industry is one of the most productive and competitive industries in the world. Many of the large pharmaceutical companies (often termed ‘Big Pharma’) base their primary operations in the USA and maintain extensive facilities in countries around the world. Pharmaceutical research is, therefore, an activity of global importance. The intensely competitive and global nature of B...

OBJECTIVE Branding medication with a known pharmaceutical company name or product name bestows on the drug an added assurance of authenticity and effectiveness compared to a generic preparation. This study examined the impact of brand name and generic labeling on medication effectiveness and side effects. METHOD 87 undergraduate students with frequent headaches took part in the study. Using a...

Dolutegravir, cabotegravir, and bictegravir are three integrase inhibitors, which were used for HIV-1 in the clinic. In this paper, a continuous three-step synthetic strategy was developed to prepare dolutegravir, better yield, compared initial step-by-step procedure. Different solvents, temperature, times optimized. course of industrial production active pharmaceutical ingredient (API), protoc...

Self-emulsifying drug delivery systems (SEDDS) have the potential to enhance bioavailability and therapeutic impact of active ingredients that are poorly water-soluble, low pemeability unstable. The ingredient, oil, surfactant, co-surfactant and/or co-solvent main elements SEDDS. Supersaturable SEDDS been developed increase efficiency ingredient loading by incorporating precipitation inhibitors...

Simunek J., Eva Hegerova, Jaroslava Klimeliova and Radka Zavadilova: Effect of Sulphadimidine on the Toxicity of Phenobarbital in Cockerels of Different Ages. Acta vet. Brno, 54,1985 : 183-187. Acute toxicity (LD50) of phenobarbital sodium salt administered intramuscularly alone and after premedication with sulphadimidine sodium salt (in i. m. doses of 0.2 gjkg body mass) given 15 or 120 minute...

This work demonstrated the importance of pre-formulation studies and proposed a generalised scheme for excipient screening in early stage amorphous solid dispersion(ASD) system development by profiling excipients’ capability to solubilise, amorphisise, stabilise chosen active pharmaceutical ingredient (API) an effort rank their suitability. Lumefantrine, antimalarial compound with both poor sol...

Terahertz pulsed imaging (TPI) is a recent and nondestructive technique to quantify coating thickness of pharmaceutical tablet film coatings. In this study, TPI is used for the first time to quantify the progress of an active coating process. The dosage form consisted of a push-pull osmotic system comprising a two-layer tablet core with a functional film coating and a laser drilled hole. On top...

The presence of a degradation product of alprazolam tablets that emerged throughout a short-stability assay has been determined and properly characterized. For this purpose an efficient methodology has been successfully applied, including SPE and HPLC methods for isolation and purification, respectively. LC/MS, MS/MS, 1H NMR, 13C NMR, UV and IR have been employed for structural elucidation conf...

In herbal medicinal products the entire herbal drug or an herbal drug preparation is regarded as the active pharmaceutical ingredient, regardless of whether constituents with defined therapeutic activity are known. In quality control and stability testing of herbal medicinal products, fingerprint chromatograms are used as powerful tools to evaluate and compare the composition of compounds in su...