In recent years marked progress has been made in the efficacy of new anthelmintics. Many thousands of these compounds are synthesized by the pharmaceutical industries and the primary and secondary laboratory animal screens, through which they pass initially, have been carefully described and reviewed in the literature(Standen, 1963; Baker, 1963). After undergoing these tests promising compounds...

Lentinula edodes is a macrofungus with great potential for therapeutic applications and serves as a model for investigating functional fungi properties and isolating pure compounds for pharmaceutical use. Mushrooms have a great nutritional value and present medicinal molecules including polysaccharides, terpenoids, sterols and lipids, that participate actively in several human disorders and mod...

In recent years there has been considerable interest in the synthesis and separation of enantiomers of organic compounds especially because of their importance in the biochemistry and pharmaceutical industry. High-performance liquid Chromatography is a very useful method for the direct separation of enantiomers. However, about 30−40 years ago, commercially available chiral stationary phases wer...

BACKGROUND High attrition rates in drug discovery call for new approaches to improve target validation. Academia is filling gaps, but often lacks the experience and resources of the pharmaceutical industry resulting in poorly characterized tool compounds. DISCUSSION The SGC has established an open access chemical probe consortium, currently encompassing ten pharmaceutical companies. One of it...

Heteroacyclic and Heterocyclic containing drugs showed remarkable and noticeable drug absorption, transmission and drug effects; hence they created their own identity and importance in pharmaceutical, medicinal, agricultural and drug sciences. Thioamido, pyridino, thiobiureto and alkylamino heterocyclic compounds showed various significances and applications in industrial, pharmaceutical, medic...

Computational screening of databases has become increasingly popular in the pharmaceutical research. Virtual screening uses computer based methods to discover new ligands on the basis of biological structures. Virtual screening is divided into structural based screening (docking) and screening using active compounds as templates (ligand based virtual screening). Ligand based screening technique...

Carboxymethyl cellulose acetate butyrate (CMCAB) has gained increasing importance in several fields, particularly in coating technologies and pharmaceutical research. CMCAB is synthesized by esterification of CMC sodium salt with acetic and butyric anhydrides. CMCAB mixed esters are relatively high molecular weight (MW) thermoplastic polymers with high glass transition temperatures (Tg). CMCAB ...

OBJECTIVE To monitor the presence of pharmaceutical residues of 14 psychoactive drugs belonging to three therapeutic groups in the watersheds of Galicia (Spain). METHOD Five sewage treatment plants were selected in the main cities of Galicia. Thirteen psychoactive pharmaceutical compounds and one metabolite were chosen. In addition, tap water samples were taken from public places and private ...

As a component of drinks, food, cosmetics, and spice, hops yields plethora biologically active compounds. This plant, which was valued by gods kings through the history, may serve as basis for pharmaceutical exploitation: not only healthy folk medicine but also in search effective sedative, estrogenic, antimicro­bial, antidiabetic, cancerostatic compounds.
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High-throughput screening (HTS) is an efficient technological tool for drug discovery in the modern pharmaceutical industry. It consists of testing thousands of chemical compounds per day to select active ones. This process has many drawbacks that may result in missing a potential drug candidate or in selecting inactive compounds. We describe and compare two statistical methods for correcting s...