This work extends the pharmaceutical cocrystal landscape of ethenzamide looking for structure-properties relationship that contributes to rational design multicomponent drugs.

background and objectives: resistance towards reveling antibiotics has captured great interest in evaluating the antimicrobial properties of the natural plants. taraxacum mongolicum is widely used as a folklore medicinal plant for its diuretic, antirheumatic and anti-inflammatory properties. though there are some reports on antimicrobial properties of taraxacum mongolicum, studies on antibacter...

Genetic and biochemical research is providing new information on the mechanism of chloroquine resistance. Drug discovery initiatives are finding new leads that have favorable pharmaceutical properties and efficacy against chloroquine-resistant malaria.

We report herein new synthetic glycolipid dimers and polymers that provide unprecedented stability to both supported (SLBs) and vesicular lipid bilayers against dehydration and serum exposure. These novel physical properties will enable pharmaceutical delivery and development of SLB bioanalytical devices.

thyme essential oils (eo) with antimicrobial and antioxidant properties are widely used in pharmaceutical, cosmetic, and perfume industry. it is also used for flavoring and preservation of several foods. nowadays, packaging research is receiving a considerable attention due to the development of eco-friendly materials made from natural polymers such as starch and chitosan. in this study thymus ...

indole is a nitrogen-containing heterocycle. it is a very important motif in agriculture and pharmacy. many compounds containing indole moiety has been isolated form nature. it is also an important part in natural alkaloids. tryptophan is an amino acid which posses indole. 3-sustituted indoles are the main group of its derivatives. because the wide-spread application of 3-substituted indolic co...

A drug discovery is characterized by two stages. The first in terms of time is called „lead structure“, followed by a so called „drug candidate“ stage. The lead structure stage involves selecting the optimum molecule of the pharmaceutical, while drug candidate stage means selecting the optimum solid form. Usually, 5 – 10 candidates pass to the drug candidate stage and the result is the selectio...

ADME-Tox properties are very important in pharmaceutical research, determining the fate of many molecules in the drug design sequence. Knowledge of ADME-Tox properties in the earliest stages of drug design is therefore highly desirable. The aim of this investigation is to construct low throughput in silico QSAR models in which ADME-Tox properties of single compounds are predicted with high accu...

BACKGROUND When new pharmaceutical products appear on the market, physicians need to know whether they are likely to be useful in their practices. Physicians currently obtain most of their information about the market release and properties of new drugs from pharmaceutical industry representatives. However, the official information contained in the summary of product characteristics (SPCs) and ...

to create values in the working environment and to achieve the organizational aims, organizations have to manage their elements with specific alignment.in principle, different departments of organizations are put together with specific arrangements and tasks in order to create value for the stakeholders .it has been proven that creating value and the outcome of an organization has a direct rela...