Purpose In the Gemeinschaftskrankenhaus Herdecke (GKH) children and adolescents with cancer are routinely treated with integrative medicine approaches. In addition to guideline-based conventional treatment a multimodal therapy concept is applied which includes anthroposophic pharmacotherapy (particularly mistletoe extracts) and non-pharmacologic therapies (e.g. art-therapies, external embrocati...

Pharmacologic- and gene-based therapies have historically been developed as two independent therapeutic platforms for cystic fibrosis (CF) lung disease. Inhibition of the dysregulated epithelial Na channel (ENaC) is one pharmacologic approach to enhance airway clearance in CF. We investigated pharmacologic approaches to enhance CFTR gene delivery with recombinant adeno-associated virus (rAAV) a...

BACKGROUND Sinus node dysfunction, atrioventricular (AV) block and atrial fibrillation (AF) are associated with advanced age. Required therapy commonly includes pacemaker implantation. METHODS We report the course of therapy for an 87-year-old with symptomatic sinus node dysfunction and paroxysmal atrial fibrillation who was intolerant of drug therapy. RESULTS The patient received a pacemak...

BACKGROUND: Much has been learned in recent years about the diagnosis and treatment of depression, a serious, commonly overlooked psychiatric illness often seen initially by the primary care physician. The objective of this article is to review the diagnosis and treatment of depression in primary care practice. METHOD: Relevant articles on depression were identified by a comprehensive MEDLINE s...

Objective To assess improvement in autonomic symptoms and functional impairment following immunotherapy with subcutaneous immunoglobulin (SCIG) or plasmapheresis (PLEX) patients postural orthostatic tachycardia syndrome (POTS). Background POTS is a common disorder defined by an increased heart rate of at least 30 bpm within 10 minutes standing tilt table test, accompanied intolerance, fatigue, ...

While parental or oral anticoagulation remains a mainstay of therapy for thrombosis, in sporadic clinical situations, percutaneous mechanical thrombectomy is favored. Percutaneous well-tolerated subtype catheterdirected intervention resulting thrombus breakdown and removal. This procedure combines endovascular combination with pharmacologic thrombolysis allowing significant reduction time. Simi...

patients with allergic rhinitis (ar) show increased production of the th2-related cytokines. almost always, intranasal corticosteroid (inc) and antihistamine are used as routine therapy of ar. this study was performed to determine the in vitro secretion of cytokines profiles of pbmcs in patients with ar sensitive to chenopodium album (ch.a) pollens before and after treatment with inc (fluticaso...

Although behavioral and surgical therapies are currently the mainstay of treating stress urinary incontinence (SUI), medications to treat SUI may possibly become first-line therapy. Currently, there are no medications approved by the US Food and Drug Administration that are indicated for SUI. However, results are becoming available on duloxetine, an oral medication that appears to be clinically...

Description This guideline updates the 2008 American College of Physicians (ACP) recommendations on treatment of low bone density and osteoporosis to prevent fractures in men and women. This guideline is endorsed by the American Academy of Family Physicians. Methods The ACP Clinical Guidelines Committee based these recommendations on a systematic review of randomized controlled trials; system...

Iatrogenic Cushing's syndrome is an undesirable outcome of glucocorticoids treatment. It can be increased by pharmacologic interactions. Glucocorticoid therapy, given in association with ritonavir, and some azole treatments are causes of iatrogenic Cushing's syndrome. We present a patient with common-variable immunodeficiency who received 7 years of itraconazole therapy for bronchial colonizati...