Capillary electrophoresis (CE) poses unique challenges in many different analytical applications, mainly to biological and complex samples and when only small amounts of sample are available, due to its low sample consumption. As a consequence, poor limits of detection are usually observed with this technique, especially with UV photodetectors. Minimal or no sample treatment is desirable in any...

in this study, for the analysis of human urine samples, a novel method explained for the determination of celecoxib, a nonsteroidal anti-inflammatory drug (nsaid), using molecularly imprinted solid-phase extraction (mispe) coupled with high-performance liquid chromatography (hplc). the synthesis of the mip was performed by precipitation polymerization in methacrylic acid (maa), ethylene glycol ...

This research paper presents findings of an investigation about antibacterial effect of methanol/water fractions as well as cytotoxic activity of the extracts obtained from Pedicularis wilhelmsiana (Scrophulariaceae) which grows in Azarbaijan/Iran by agar well diffusion method and brine shrimp lethality test successively. Phytochemical study of this plant was determined as well. A combination o...

Abstract Bitumen is a complex mixture consisting of different hydrocarbons, which can be categorised into substance classes called SARA (saturates, aromatics, resins and asphaltenes) fractions. The saturates, aromatics are further referred to as maltenes or maltene phase. To determine the fractions asphaltenes were separated from in first step. A standard method separate column chromatography (...

A generic method was developed for the fast determination of a wide range of drugs in serum or plasma. The methodology comprises generic solid-phase extraction, on-line coupled to gradient HPLC with tandem mass spectrometric detection (SPE-LC-MS/MS). The individual components of the SPE-LC-MS/MS system were optimized in an integrated approach to maximize the application range and minimize the m...

This chapter focuses on three widely used techniques for extraction of semivolatile organics from liquids: liquid–liquid extraction (LLE), solid-phase extraction (SPE), and solid-phase microextraction (SPME). Other techniques may be useful in selected circumstances, but these three techniques have become the extraction methods of choice for research and commercial analytical laboratories. A fou...

Abuse and residues of antibiotics cause great harm to organisms the environment. Appropriate sample pretreatment is usually required for sensitive determination, because low content presence a variety in complicated matrices. Molecular-imprinting-based solid-phase extraction (MISPE) has been widely used antibiotics, using molecularly imprinted polymers (MIPs) as adsorbents. Herein, we comprehen...

Mycotoxins can contaminate various food commodities, including cereals. Moreover, mycotoxins of different classes can co-contaminate food, increasing human health risk. Several analytical methods have been published in the literature dealing with mycotoxins determination in cereals. Nevertheless, in the present work, the aim was to propose an easy and effective system for the extraction of six ...

Abstract: Aim: The current study was aimed to develop and validate a simple isocratic, precise, sensitive, accurate robust reverse phase HPLC analytical method for the quantification of total, free entrapped ritonavir in lipid nanocarriers drug content film-coated fixed-dose formulation. Materials Methods: developed by using Inertsil ODS-3V C18 column as stationary phase, orthophosphoric acid (...

A screening method using gas chromatography quadrupole time-of-flight mass spectrometry (GC-QTOF/MS) combined with mini solid-phase extraction (mini-SPE) was established for the quantification and validation of multiclass pesticide residues in tobacco. The quicker easier, sample purity higher than that obtained by traditional SPE dispersed-SPE. Box-Behnken design, an experimental design respons...