in this study, data comprising 10479 production and reproduction records of razavi khorasan province's dairy cattle, were collected by animal breeding center of iran during 1986 to 2006, were used. genetic parameters were estimated by restricted maximum likelihood procedure using wombat software. genetic and phonotype trends were estimated via linear regression as means genetic and phonotype va...

Fertility, represented by calving interval, has been included in the genetic evaluation of Icelandic cattle since 1993. In spite this an unfavourable trend is seen and, recent implementation test-day models for milk production changed premise using interval to represent fertility. The aim study was estimate parameters and trends different female fertility traits dairy suggest new evaluation. In...

Objective(s): Granular and lattice corneal dystrophies (GCDs & LCDs) are autosomal dominant inherited disorders of the cornea. Due to genetic heterogeneity and large genes, unraveling the mutation is challenging.Materials and Methods: Patients underwent comprehensive clinical examination, and targeted next-generation sequencing (NGS) was...

celiac disease is a chronic, systemic and autoimmune disorder of gastrointestinal track that involves approximately 1% of individuals of all ages throughout the world. the collaboration of environmental factor such as gluten proteins and genetic factors, notably hla-dq2 and/or hla-dq8 trigger the disease. gluten-free diet is the simply and merely safe and proficient existing treatment. this art...

each country faces a continuing challenge to collect enough blood to meet the national needs. according to who, there should be at least 20 blood donations per 1,000 population for developing countries, in kazakhstan this indicator was only 16.8 in 2011. thus, we conducted an epidemiological assessment and drew a map of the regional distribution of blood and plasma donations in kazakhstan durin...

Background: Wiskott-Aldrich syndrome (WAS) is an X-linked recessive disorder associated with combined immunodeficiency, microthrombocytopenia, eczema, and increased risk of autoimmunity cancer. Aim: To report the clinical presentation, immune features, genetic mutation in a patient novel gene, causing mild phenotype WAS. Methods: The patient’s chart was reviewed. We phenotypical laboratory char...

Background: Breast cancer is one of the most common malignancies among Iranian women; however, its clinicopathological feature is uncertain. We pioneered a genetic counseling program among patients with breast cancer and their families in Isfahan. This is the first report of this program. Methods: This was a descriptive cross-sectional study on women with breast cancer registered in Ala Cancer...