Diels-Alder polyphenylenes (DAPPs) are chemically and thermally stable polymers, used for dielectric resins, gas separation membranes, and fuel cell proton exchange membranes. Highly fluorinated DAPPs are expected to have better thermal stability and chemical resistance, higher glass transition temperatures, improved compatibility with other fluorinated polymers (like Nafion), and better adhesi...

Cultures of trunk neural crest cells from quail embryos were tested for their ability to release [3H]norepinephrine ([3H]NE) in response to depolarization. After 7 days in. uitro, exposure of the cultures to either the alkaloid veratridine or 40 mM K+ results in the evoked release of [3H]NE. The release evoked by veratridine is blocked in the presence of tetrodotoxin. The release evoked by incr...

Alix, Philippe, Francoise Grolleau, and Bernard Hue. Ca /Calmodulin-dependent protein kinase regulates GABA-activated chloride current in cockroach dorsal unpaired median (DUM) neurons. J Neurophysiol 87: 2972–2982, 2002; 10.1152/jn.00631.2001. We studied -aminobutyric acid (GABA)-mediated currents in short-term cultured dorsal unpaired median (DUM) neurons of cockroach Periplaneta americana us...

Introduction: Diffusion-weighted imaging (DWI) signal attenuation in the brain is non-monoexponential [1,2]. Understanding the source of non-monoexponential behavior may lead to an improved characterization of the tissue during disease. Several phenomenological models have been developed to describe this data. Two such models are stretched exponential (αDWI) [3] and second-order cumulant [6] fi...

BACKGROUND Epithelial cells in malignant conditions release DNA into the extracellular compartment. Cell free DNA of tumor origin may act as a ligand of DNA sensing mechanisms and mediate changes in epithelial-stromal interactions. AIMS To evaluate and compare the potential autocrine and paracrine regulatory effect of normal and malignant epithelial cell-related DNA on TLR9 and STING mediated...

Introduction: Diffusion weighted imaging (DWI) has been effectively used to detect ischemic stroke [1,2]. Although its underlying physical mechanism remains unknown, the restricted diffusion at the early stage is likely caused by cytotoxic edema, and the subsequent escalated diffusion might arise from the vasogenic edema [2, 3]. The diffusion in water compartments during cytotoxic edema was val...

Despite intensive medication development efforts, no effective pharmacotherapy for cocaine abuse has demonstrated efficacy for long-term use. Given the obvious importance of the dopamine transporter in the addictive properties of cocaine, the development and use of compounds that target the dopamine transporter represents a reasonable approach for the pharmacological treatment of cocaine abuse....

Up-regulation of vascular cell adhesion molecule-1 (VCAM-1) involves adhesions between both circulating and resident leukocytes and the human tracheal smooth muscle cells (HTSMCs) during airway inflammatory reaction. We have demonstrated previously that tumor necrosis factor (TNF)-induced VCAM-1 expression is regulated by mitogen-activated protein kinases, nuclear factorB, and p300 activation i...

Several novel N-arylpiperazine derivatives were synthesized and tested for their 1) affinity and functional activity on 5-hydroxytryptamine1A (5-HT1A) receptors in vitro; 2) activity in models predictive of antagonism at somatodendritic and postsynaptic 5-HT1A receptors; and 3) effects on the micturition reflex in anesthetized and conscious rats. These studies also included 1-(2-methoxyphenyl)-...

The novel, potential anxiolytic, S 15535 (4-(benzodioxan-5-yl)1(indan-2-yl)piperazine), is an agonist and antagonist (weak partial agonist) at preand postsynaptic serotonin (5-HT)1A receptors, respectively. Herein, we characterized its influence on dialysate levels of 5-HT, dopamine (DA) and NAD simultaneously determined in single samples of the frontal cortex (FCX) of freely moving rats, and c...