This paper reviews studies performed by the authors and by others on the levels of high energy phosphate compounds-adenosine triphosphate (ATP), adenosine diphosphate (ADP), and creatine phosphate (CP )-of cardiac muscle under various conditions influencing contractile force. Interference with energy metabolism decreases both contractile force and high energy phosphates, especially CP. Certain ...

The relationship between occupancy of thrombin receptors on platelets and enhanced phosphoinositide hydrolysis was analysed by examination of the dose-response relationship, the effects of thrombin inhibitors and the contribution of secondary effects. Washed human platelets were labelled with [3H]inositol, and agonist-induced accumulation of labelled inositol phosphates was measured. (1) The do...

Phosphate rocks are a vital resource for world food supply and security. They the primary raw material phosphoric acid fertilizers used in agriculture, increasingly considered to be potential source of rare earth elements. occur either as sedimentary deposits or igneous ores associated with alkaline rocks. In both cases, genesis high-grade phosphate results from complex concentration mechanisms...

The stimulation of the formation of inositol phosphates by various cholinergic agonists and antagonists was studied in rat brain cortical slices. Incubation of the slices with [3H]inositol led to the incorporation of radioactivity into inositol lipids. The accumulation of inositol phosphates was then followed in the presence of 8 mM lithium which blocks the hydrolysis of inositol phosphate. The...

Degradation of organophosphoric esters (OPEs) in leachate from a sea-based solid waste disposal site was investigated by laboratory experiment. Aryl-phosphates, tricresyl phosphate and triphenyl phosphate, in leachate rapidly decreased to less than the detection limit within 20 days under aerobic condition, suggesting high biodegradability. These phosphates also decreased in sterilized leachate...

We examined the effect of EGF and angiotensin II (AII) on the formation of inositol phosphates and aldosterone secretion, and observed the role of tyrosine phosphorylation in EGF or AII-mediated aldosterone secretion. As cultured glomerulosa cells were incubated with increasing concentrations of EGF (0.01-100 ng/mL), aldosterone secretion increased and reached a plateau at EGF concentration of ...