نتایج جستجو برای: phosphodiesterase 4
تعداد نتایج: 1312167 فیلتر نتایج به سال:
The effects of several phosphodiesterase (PDE) inhibitors on the L-type Ca current (I(Ca)) and intracellular cyclic AMP concentration ([cAMP]i) were examined in isolated rat ventricular myocytes. The presence of mRNA transcripts encoding for the different cardiac PDE subtypes was confirmed by RT-PCR. IBMX (100 microM), a broad-spectrum PDE inhibitor, increased basal I(Ca) by 120% and [cAMP]i by...
Phosphodiesterase is an enzyme that degrades the phosphodiester bond in second messenger molecules cAMP and cGMP, regulates localization, duration, amplitude of cyclic nucleotide signaling within subcellular domains. Sildenafil a potent selective inhibitor type 5 cGMP-specific phosphodiesterase used clinically to treat erectile dysfunction pulmonary arterial hypertension. In this study, we exam...
The role of the phosphodiesterase-4 inhibitor, roflumilast, in chronic obstructive pulmonary disease
A conceptually new and general strategy has been developed for the construction of a benzimidazole or a benzoxazole ring fused with isoquinolinone affording a diverse and unique class of small molecules as potential and novel inhibitors of PDE4.
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