Various approaches leading to mono-, diand poly-functionalized phosphonates as well as phosphoryl heterocycles were reported for the systematic study of relationship between chemical structure and biological activities of this most important class of organophosphorus compounds. Introduction Functionalization of phosphonic acid molecules opens enoi-nious possibilities of structural variation of ...

Tritiated thymidine routinely labels onion root cytoplasm during most of the cell cycle. One-third of this label could be cytochemically identified as DNA. The balance of the label was not RNA or a lipid, or attributable to labeled impurities in thymidine-(3)H. In electron microscope radioautographs one-third of the cytoplasmic silver grains was over organelles, presumably mitochondria and plas...

Intramolecular homolytic substitution (SHi) on the sulfur atom at acyclic N-(o-bromobenzyl)sulfinamides takes place with a complete inversion of the configuration and provides an excellent tool to connect N-tert-butanesulfinylimines with enantiopure 3-substituted benzo-fused sulfinamides (1,2-benzoisothiazoline 1-oxides) and the related pharmacologically relevant sulfonamides.

[reaction: see text] Palladium-catalyzed coupling reaction of N,N-dimethylformamide with aryl or alkenyl halides successfully proceeded in the presence of phosphoryl chloride to afford the corresponding tertiary amides in good yields.

Upon illumination of spinach chloroplasts in the presence of [32P]orthophosphate and AMP and absence of substrate ADP, coupling factor-bound [32P]ADP is formed. This bound r3’P]ADP is stable enough to withstand purification of the coupling factor to homogeneity. However, the ability of this specially bound [““PIADP to serve as the ultimate phosphoryl donor to substrate ADP for the synthesis of ...

While investigating the enzymatic conversion of n-glyceric acid-3phosphoric acid to pyruvic acid and phosphoric acid, an essential step both in glycolysis and fermentation, Meyerhof and Lohmann (1) observed the formation of a hitherto unknown organic phosphoric acid ester. They succeeded in isolating the new intermediary compound by virtue of the ease of crystallization of the silver-barium sal...