PURPOSE Riboflavin/ultraviolet A (UVA) cross-linking (CXL) of corneal collagen is a novel method of stabilizing corneal mechanical properties and preventing progression of keratectasias. This study was conducted to investigate whether CXL influences ablation rate, flap thickness, and refractive results of excimer laser procedures ex vivo. METHODS Corneal epithelium was removed from enucleated...

A 30-year-old white male underwent LASIK by another surgeon in July 1998 with a VISX STAR laser (VISX, Inc., Santa Clara, CA) and a Moria LSK microkeratome (Moria, Antony, France) to correct moderate myopia: -5.50 D sphere OD, -6.00 D sphere OS, and a BCVA of 20/20 OU. His preoperative corneal thicknesses were 548 and 555 μm OD and OS, respectively. The initial LASIK surgery resulted in an over...

Subcellular localization of photosensitizers (PSs) determines the therapeutic efficacy in the photodynamic therapy. However, among the subcellular compartments, there has been little effort to deliver the PSs selectively into the plasma membrane and examine the phototherapeutic efficacy of membrane-localized PSs. Here, we developed a liposomal delivery system to localize the hydrophobic PSs sel...

BACKGROUND Hevin is a matricellular protein involved in tissue repair and remodeling via interaction with the surrounding extracellular matrix (ECM) proteins. In this study, we examined the functional role of hevin using a corneal stromal wound healing model achieved by an excimer laser-induced irregular phototherapeutic keratectomy (IrrPTK) in hevin-null (hevin(-/-)) mice. We also investigated...

PURPOSE To evaluate the use of high-frequency ultrasound biomicroscopy (UBM) in determining the depth of corneal pathology in eyes undergoing excimer laser phototherapeutic keratectomy (PTK) for primary or recurrent anterior stromal corneal dystrophies. Corneal clarity, visual acuity and refractive changes in eyes with and without an antihyperopia treatment were also analyzed. METHODS Twenty ...

PURPOSE To assess the findings, visual morbidity, and surgical intervention in Schnyder crystalline corneal dystrophy (SCCD). METHODS Retrospective case series of 115 affected individuals from 34 SCCD families identified since 1989. Age, uncorrected visual acuity, best-corrected visual acuity (BCVA), corneal findings, and ocular surgery were recorded. Prospective phone, e-mail, or written con...

BACKGROUND Scleroderma is a chronic autoimmune disease characterized by progressive connective tissue sclerosis and microcirculatory changes. Localized scleroderma is considered a limited disease. However, in some cases atrophic and deforming lesions may be observed that hinder the normal development. Literature reports indicate phototherapy as a therapeutic modality with favorable response in ...

NOVEMBER/DECEMBER 2012 CATARACT & REFRACTIVE SURGERY TODAY EUROPE 1 A ccuracy of biometric calculations and, more important, of refractive results depends on three main factors: preoperative biometric data including axial length, anterior chamber depth, lens thickness, and corneal curvature power variables; power calculation formulas; and quality and accuracy of the IOL. In the past 15 years, s...

AIMS To evaluate the efficacy and safety of diamond burr superficial keratectomy in the treatment of recurrent corneal erosions. METHODS A retrospective review of 54 eyes (47 patients) with recurrent corneal erosions treated with diamond burr superficial keratectomy. Preoperative and postoperative visual acuities and refractions, slit lamp examination findings, and the incidence of recurrent ...