Shift work exerts major influences on the physiological functions of the human body. These are primarily mediated by the disruption of circadian rhythms since most body functions are circadian rhythmic. Next to the disturbances caused by changes in the circadian system, shift work has also been suggested to be related to a number of other health disorders. The present study summarizes recently ...

Circadian variations are observed in many physiological processes, and alterations in these oscillations are closely linked to mood disorders, metabolic abnormalities and cardiovascular complications. The nuclear receptor Rev-erba is a crucial component of the clock mechanism. It is an important metabolic regulator and a target for lithium, a drug used in the treatment of bipolar disorders. The...

Insomnia is a common disorder among the general population, which has chronic course and heavy burden on patients health care system. Epidemiological papers sleep disorders show that large number of people complain disorders. Today, there are several classifications definitions for disorders, first all insomnia. Insufficient can contribute to occurrence rapid fatigue during daytime, reduced act...

Introduction Elevated blood levels of homocysteine have been associated with several psychiatric and neurodegenerative disorders such as schizophrenic disorders, Alzheimer’s disease, Parkinson’s disease depression. The hypothesis is that genetic environmental factors elevate levels, which causes vascular diseases the brain, and/or changes in neurotransmitters, cause various mental disorders. Ob...

The difficulty to understand, diagnose, and treat neurological disorders stems from the great complexity of the central nervous system on different levels of physiological granularity. The individual components, their interactions, and dynamics involved in brain development and function can be represented as molecular, cellular, or functional networks, where diseases are perturbations of networ...