نتایج جستجو برای: pick c
تعداد نتایج: 1066027 فیلتر نتایج به سال:
The molecular isolation of NPC1 and NPC2, the genes defective in patients with Niemann-Pick disease type C (NP-C), has heralded in an exponential increase in our understanding of this syndrome and thus of human intracellular sterol transport. Despite this, neither the mechanisms of action nor the substrates for these putative transporters have been defined. In this overview, we describe our per...
[This corrects the article DOI: 10.1155/2015/807591.].
Niemann-Pick type C (NPC) disease is a fatal, neurodegenerative disorder caused in 95% of cases by loss of function of NPC1, a ubiquitous endosomal transmembrane protein. A biochemical hallmark of NPC deficiency is cholesterol accumulation in the endocytic pathway. Although cholesterol trafficking defects are observed in all cell types, neurons are the most vulnerable to NPC1 deficiency, sugges...
People homozygous for mutations in the Niemann-Pick type C1 (NPC1) gene have physiological defects, including excess accumulation of intracellular cholesterol and other lipids, that lead to drastic neural and liver degeneration. The NPC1 multipass transmembrane protein is resident in late endosomes and lysosomes, but its functions are unknown. We find that organelles containing functional NPC1-...
Reduced astrocytic gap junctional communication and enhanced hemichannel activity were recently shown to increase astroglial and neuronal vulnerability to neuroinflammation. Moreover, increasing evidence suggests that neuroinflammation plays a pivotal role in the development of Niemann-Pick type C (NPC) disease, an autosomal lethal neurodegenerative disorder that is mainly caused by mutations i...
تصمیمگیری در روابط عاشقانه مثل شروع یک دوره آشنایی، پیشنهاد ازدواج یا پایان دادن به یک رابطه میتواند عواقب درازمدت و مهمی داشته باشد. هدف پژوهش حاضر بررسی اثر بخشی آموزش قبل از ازدواج به شیوه برنامه آگاهی و انتخاب های بین فردی (PICK) بر تصمیم گیری دانشجویان مجرد بود. پژوهش حاضر نیمه آزمایشی با طرح پیش آزمون و پس آزمون با گروه کنترل بود. 36 دانشجوی مجرد بر اساس نمره یک انحراف معیار پایین ...
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