Data Mining approaches have been widely applied in the field of healthcare to facilitate the quality diagnosis. The physiologic state and the complexity of disease of a patient is monitored through diverse variety of symptoms and laboratory test measurements. Data acquisition in healthcare systems is voluminous; they come from many different sources, not all commensurate structure or quality. T...

A polymorphism in FABP2 that results in an alanine-to-threonine substitution at amino acid 54 of the intestinal fatty acid-binding protein (IFABP) is associated with insulin resistance in Pima Indians. In vitro, the threonine form (Thr54) has a higher binding affinity for long-chain fatty acids than does the alanine form (Ala54). We tested whether this polymorphism affected metabolic responses ...

Design, setting, participants, & measurements In this longitudinal study, GFR was measured serially over approximately 4.0 years in 195 Pima Indians with type 2 diabetes. Renal function decline (RFD) was defined during this initial period by an average GFR loss $3.3%/yr, as defined previously in type 1 diabetes. Subsequently, participants were followed for up to 17.8 years to ESRD onset, death,...

Diabetes mellitus affects up to 6% of the UK population, although it is estimated that around half of these individuals remain undiagnosed. It occurs equally in both sexes but varies with age and race. The ethnic group at highest risk is the Pima Indians in North America with a 50% prevalence of diabetes. Other high-risk groups include the Afro-Caribbean and Asian populations, who are at four t...