BACKGROUND Inhalation of lipopolysaccharide (LPS) causes an inflammatory response in the lungs. To explore this response, inflammatory indices were measured in induced sputum from atopic asthmatic patients and compared with atopic and non-atopic subjects after inhalation of LPS. METHODS The effects of inhaled LPS (60 micrograms) or placebo (0.9% saline) were examined in a randomised, double b...

background: considering the dramatic increasing rate of diabetes and consequently its related complications, most importantly diabetic peripheral neuropathy (dpn), challenges regarding proper treatment of dpn and its effect on the quality-of-life and care of diabetic patients, the aim of this current study is to evaluate the effect of intradermal botulinum toxin type a (btx-a) injections on pai...

Abstract Purpose of the review This narrative highlights recent literature pertaining to available intra-articular (IA) therapeutics such as corticosteroids, hyaluronic acid (HA), platelet-rich plasma (PRP), stem cells therapy, and prolotherapy for knee osteoarthritis (OA) by summarizing recently published treatment guidelines clinical trials, discusses opinion future directions. Recent finding...

OBJECTIVES/HYPOTHESIS We aimed to evaluate the effectiveness of low-concentration hypochlorous acid (HOCl) nasal irrigation compared to isotonic normal saline for pediatric chronic rhinosinusitis. STUDY DESIGN This was a randomized, prospective, active-controlled study. METHODS This study investigated the effectiveness of 4 weeks of low-concentration hypochlorous irrigation by analyzing fiv...

Background: Progesterone as a sex steroid hormone is thought to affect and prevent demyelination, but its role in promoting myelin repair is far less investigated. In this study, remyelinating potential of progesterone in corpus callosum was evaluated on an experimental model of MS.Methods: In this experimental study, adult male C57BL/6 mice were fed with 0.2% (w/w) cuprizone in ground breeder ...

Objective: To observe the pre-emptive effect of intravenous paracetamol versus ketorolac in preventing postoperative shivering and pain after septoplasty care unit.
 Study Design: Prospective comparative study.
 Place Duration Study: Main Operation Theatre Frontier Corps Hospital Quetta, from Sep to Dec 2019.
 Methodology: After ethical committee approval, 90 American Society Ana...

Inhibitors of angiotensin converting enzyme may cause angio-oedema. To see if this might be due to potentiation of the tissue effects of bradykinin the thickness of weals raised by intradermal injection of saline or 1, 3, or 10 micrograms bradykinin was measured before and three times after single doses of captopril, enalapril, or placebo. The mean thickness increased with increasing doses of b...

Leg ulcers are a chronic manifestation of sickle-cell disease (SCD) and are often painful, disabling, and difficult to treat. RGD peptide matrix treatment is a novel therapy designed to provide a topical synthetic extracellular matrix that can act as a temporary substitute for the damaged natural matrix at the ulcer site. In this randomized, placebo-controlled, double-blind, prospective, multic...

AIMS To test the hypothesis that inhaled salbutamol or beclomethasone will reduce the frequency of cough in children with recurrent cough. A secondary aim was to determine if the presence of airway hyperresponsiveness (AHR) can predict the response. DESIGN Randomised, double blind, placebo controlled trial. METHODS During a coughing phase, 43 children (age 6-17 years) with recurrent cough w...