PURPOSE To evaluate the plaque- and gingivitis-reducing efficacy of a newly developed multi-directional power toothbrush in comparison to a commercially-available sonic power toothbrush. METHODS Adult subjects with mild-to-moderate gingivitis were eligible for this 4-week, randomized and controlled, single-center, examiner-blinded, parallel group study. At baseline, plaque and gingivitis stat...

We report the first systems biology investigation of regulators controlling arterial plaque macrophage transcriptional changes in response to lipid lowering in vivo in two distinct mouse models of atherosclerosis regression. Transcriptome measurements from plaque macrophages from the Reversa mouse were integrated with measurements from an aortic transplant-based mouse model of plaque regression...

AIM This 4-week, single-centre, randomized, examiner-blind, controlled study investigated the efficacy and safety of 0.15% ethyl lauroyl arginate (LAE)-containing mouthrinse in adults with mild-to-moderate gingivitis. MATERIAL AND METHODS Subjects were randomized to use 0.15% LAE-containing mouthrinse or 5% hydroalcohol-negative control twice daily after brushing with standard fluoride toothp...

he search for the etiologic agents of periodontal diseases started in the Golden Era of medical bacteriology, when the etiologic agents of many bacterial infections were isolated and characterized. After the initial enthusiasm in establishing the infectious nature and the true agents of periodontal diseases, this concept was virtually ignored for the next four decades. Until the early 1970s tre...

The aim our study was to evaluate the levels of zinc in blood serum, hair, and specimens of carotid artery atherosclerotic plaques (CAAPs) and their relationship to levels of MMP-9 and TIMP-1 in the serum of patients with stable and unstable CAAPs. Material and Methods: The study included 73 patients (55 men and 18 women) aged from 46 to 88 years (mean age 65.96±1.07 years) with CAAPs. The cont...

Purpose: To determine the effectiveness of a new multi-directional power toothbrush in reducing plaque when compared to a standard manual toothbrush control in a single brushing design. Methods: This was a randomized, replicate use, single-brushing, two-treatment, double blinded crossover clinical trial at a single center. Qualified subjects entered an acclimation phase, after which they were r...

BACKGROUND Recent clinical trials have demonstrated that aggressive lipid lowering by statins could prevent recurrent events after acute coronary syndrome (ACS). We hypothesized that this efficacy was caused by a significant reduction in plaque volume by aggressive LDL cholesterol (LCL-C) lowering. The present study investigated the effect of early statin treatment on plaque volume of a nonculp...

The main objective was to investigate whether low-molecular-weight fraction of edible mushroom shiitake extract (Lentinus edodes) possesses caries-preventive properties. The study was designed as a double-blind, three-leg, cross-over, randomized, controlled clinical trial carried out on two series of volunteers at the University of Gothenburg, and the Academic Centre for Dentistry Amsterdam. Vo...