Recent data have renewed the interest for arsenic-containing compounds as anticancer agents. In particular, arsenic trioxide (As2O3) has been demonstrated to be an effective drug in the treatment of acute promyelocytic leukemia by inducing programmed cell death in leukemic cells both in vitro and in vivo. This prompted us to study the in vitro effects of As2O3 and of another arsenical derivativ...

The blood donation and transfusion chain Although much effort has been expended to find suitable replacements for blood components, the best source continues to be blood collected from healthy, human donors. The process of supplying sufficient blood components and derivatives for patient needs is complex and highly regulated. At the same time, it must be dynamic in adapting to the local and reg...

Mountain pass in a suitable Orlicz space is employed to prove the existence of soliton solutions for a quasilinear Schrödinger equation involving critical exponent in RN . These equations contain strongly singular nonlinearities which include derivatives of the second order. Such equations have been studied as models of several physical phenomena. The nonlinearity here corresponds to the superf...

Cardiorespiratory and biochemical indicators typically used by contemporary elite athletes seem to have limited applicability. According to some recent studies, purine metabolism better reflects exercise response and muscle adaptation in this group. We propose using purine derivatives, especially plasma hypoxanthine concentration, as indicators of training status in consecutive training phases ...

drug toxicity. Thus Doctors Kalow, Conney, Fouts, and Remer were concerned with the effects of both individual variation in drug-metabolizing enzyme systems and of effects of other drugs such as SKF 525A on such enzymes, which can lead to marked variations in plasma levels of drug. However, as Dr. Westermann reminded us, such drugs as reserpine, monoamine oxidase inhibitors, and coumarin antico...

Four types of bovine liver catalase (CAT) derivatives, succinylated (Suc-CAT), galactosylated (Gal-CAT), mannosylated (Man-CAT), and polyethylene glycol conjugate (PEG-CAT), were synthesized and their pharmacokinetics and therapeutic potential in a hepatic ischemia/reperfusion injury model were studied in mice. About 90% of the CAT enzymatic activity was retained after chemical modification. Bi...