This paper describes an LC-MS/MS method to determine the concentration of spironolactone and its metabolites 7-alpha-methylthiospironolactone and canrenone in blood plasma samples. The resulting assay is simple (using protein precipitation for sample preparation) and sensitive (the lower limit of quantification is close to 0.5 ng/ml) while requiring only 50 μl of plasma, making it especially su...

Nearly 70-80% of the world's population relies on non-conventional medicines, often derived from herbal plants, according to World Health Organization (WHO) figure. Medicinal plants are starting material for any preparation such as teas, oil etc. These preparations being used worldwide due their therapeutic potential and they considered be safe compared allopathic medicines. Lead, cadmium, chro...

Prior to 1966, almost all available information on drug safety for marketed medicines was strictly qualitative. It was predominantly based on anec-dotal reports and clinical opinions derived primarily from the known pharmacology of particular drugs. While the medical environment for identifying and quantifying drug toxicity was generally informal and undirected, the use of anecdotal reports to ...

Herbal medicines containing emodin, widely used for the treatment of hepatitis in clinic, have been reported with hepatotoxicity in individuals. A modest inflammatory stress potentiating liver injury has been linked to the idiosyncratic drug-induced liver injury (IDILI). In this study, we investigated the hypothesis that lipopolysaccharide (LPS) interacts with emodin could synergize to cause li...

caused as lifestyle disease is increasing and has become something of a social problem in recent years. a-Glucosidase inhibitors, medicines that prevent elevation of postprandial blood glucose, can control blood glucose levels without depending on increased secretion of insulin and results in lowering the amount of insulin required after meals. A similar effect to that of these medicines can be...

background cleft palate (cp) is a common congenital defect. it makes serious difficulties for cleft-affected children. the gold standard of care is autogenous bone grafting which may cause additional problems in donor site along with disappointing results. tissue engineering is a promising solution for a widespread range of defects and disorders. it is reasonable to utilize this novel technolog...

  Propagation of dust ion acoustic waves in plasmas composed of nonthermal distributed electrons and stationary dust particles is investigated. Nonlinear Schrdinger equation is derived to describe small amplitude waves, using the reduction perturbation technique. Modulation instability of dust ion acoustic waves is analysed for this system. Parametric investigation indicates that growth rate of...

The rational use of plants as medicine is traced back over five epochs to ancient documents of early civilizations and is certainly as old as mankind. These medicines originally developed from crude drugs like tinctures and tinctures. Minimum 119 chemical substances are derived from 90 plant species and used all over the world as medicines, several of them containing compounds derived from or m...

OBJECTIVES To identify consumer information needs about paracetamol, the most commonly used analgesic and antipyretic worldwide. DESIGN Retrospective analysis of medicines questions from the public. SETTING Australian consumer medicines call centre. PARTICIPANTS Callers to National Prescribing Service Medicines Line between September 2002 and June 2010 (n=123 217). MAIN OUTCOME MEASURES...