Protein C is a vitamin K dependent plasma zymogen which acts by regulating coagulation by its specific inactivation of factors V and VII, and facilitates fibrinolysis by elevating circulating plasminogen activator levels. Protein C deficiency is a rare condition which predisposes to episodes ofpotentially blinding and lethal thromboembolism. In the newborn period, congenital protein C deficienc...

A persuasive link between hemostatic factors and cancer has been developed through extensive studies of both human and animal malignancies. Coagulation-, plateletand fibrinolytic-factors all have been tightly associated with tumor growth and/or dissemination. Nevertheless, the mechanisms by which these factors influence tumor growth and progression remain to be fully defined. Recent studies of ...

stroke is an important cause of disability and death worldwide, with the majority of strokes occurring in older people. thrombolysis with recombinant tissue plasminogen activator (r-tpa) is the approved treatment for acute ischemic stroke. a major concern of physicians, who treat acute ischemic stroke with recombinant tissue plasminogen activator (r-tpa,) is the risk of intracerebral hemorrhage...

Plasminogen, the zymogen form of the fibrinolytic enzyme plasmin, is known to undergo plasmin-mediated modification in vitro. The modified form, Lys-plasminogen, is superior to the native Glu-plasminogen in fibrin binding and as a substrate for activation by tissue-type plasminogen activator (t-PA). The present study was undertaken to determine the existence and significance of the Glu- to Lys-...