The analgesic effect of 5fluorouracil (5-FU) was analyzed in two experimental tests in mice. Two analgesia test, writhing test and hot plate test have been performed in swiss albino mice. The tested substance used was 5-Fluorouracil, i.p. administered in doses of 10 (Lethal Dose 50/10) and 20 mg/kg body weight (bw) (Lethal dose 50/5), 1 hour before tests. In the writhing test, 5-FU has signifi ...

Our previously conducted pharmacological investigations led us to discovery of the strong local anesthetic activity of the compound KP-23RS. The following studies revealed that its Rand S-diasteroisomers had different activity in the local anesthetic, anti-aggregating, anti-arrhythmic and spasmolytic tests. Also the influence of KP-23RS and its diastereoisomers on the cyclic adenosine monophosp...

The modification of the CAMP test for goup B streptococci involved substituting a paper disk impregnated with partially purified beta-hemolysin for the staphylococcal culture that was the source of beta-hemolysin in the original test. The disk is placed onto a sheep blood agar plate beside the streak of Streptococcus being tested. The plate is then incubated aerobically at 35 degrees C. A posit...

In this study, the response of female rats in different phases of the estrus cycle to nociceptive stimulation was evaluated using thermal (hot plate and tail immersion) and chemical (formalin) tests. In the hot plate test, the paw licking latency fell significantly (p < 0.05) in the metestrus and diestrus phases compared with the proestrus and estrus phases. The observations in the tail immersi...

We used the hot plate test and the formalin test to evaluate the antinociception of choline after i.c.v. or i.v. administration. The analgesic mechanism of choline was also studied. The response latency of mice was significantly prolonged in the hot plate test after choline (90-120 mug/animals) i.c.v. administration in a dose-dependent manner. Pretreatment with methyllycaconitine citrate (MLA),...

A laboratory test with a flow-through system was designed and its applicability for testing antifouling paints of varying efficacies was investigated. Six different formulations of antifouling paints were prepared to have increasing contents (0 to 40 wt.%) of Cu2O, which is the most commonly used antifouling substance, and each formulation of paint was coated on just one surface of every test p...

Our previously conducted pharmacological investigations led us to discovery of the strong local anesthetic activity of the compound KP-23RS. The following studies revealed that its R- and S-diasteroisomers had different activity in the local anesthetic, anti-aggregating, anti-arrhythmic and spasmolytic tests. Also the influence of KP-23RS and its diastereoisomers on the cyclic adenosine monopho...

the novel bicyclo thieno 1, 2, 3-triazines (btt) namely btt-1, btt-2, btt-3 and btt-4 were evaluated for analgesic anti-inflammatory and antiarthritic activity. analgesic and anti-inflammatory activity was evaluated using hot plate test , formalin induced paw licking test and formalin induced paw edema test respectively, complete fruend’s adjuvant (cfa) induced arthritis model was used for anti...