نتایج جستجو برای: pluripotency specific

تعداد نتایج: 1040520  

2017
Austin Smith

The regulative capability of single cells to give rise to all primary embryonic lineages is termed pluripotency. Observations of fluctuating gene expression and phenotypic heterogeneity in vitro have fostered a conception of pluripotency as an intrinsically metastable and precarious state. However, in the embryo and in defined culture environments the properties of pluripotent cells change in a...

Journal: :Russian Journal of Plant Physiology 2021

Abstract Plant cells cultivated in vitro are a convenient model for studying the genetic and physiological mechanisms necessary to acquire state of pluripotency. Earlier studies on plant Arabidopsis thaliana (L.) Heynh. have identified key role genes that determine pluripotency shoot apical meristem de novo regeneration tissue culture. In accordance with this, mutant plants higher level express...

Journal: :Journal of cell science 2005
Ludovic Vallier Morgan Alexander Roger A Pedersen

Maintenance of pluripotency is crucial to the mammalian embryo's ability to generate the extra-embryonic and embryonic tissues that are needed for intrauterine survival and foetal development. The recent establishment of embryonic stem cells from human blastocysts (hESCs) provides an opportunity to identify the factors supporting pluripotency at early stages of human development. Using this in ...

2018
Yu-Jing Liao Yi-Shiou Chen Ja-Xin Lee Lih-Ren Chen Jenn-Rong Yang

OBJECTIVES The importance of Oct4 and Sox2 in maintaining pluripotency and self-renewal is well-understood, but the functions of Klf4 and c-Myc has not been fully investigated. In the present study, we attempted to determine the roles of Klf4 and c-Myc on pluripotency maintenance of porcine induced pluripotent stem (piPS) cells. MATERIALS AND METHODS In this experimental study, we performed s...

Journal: :Current opinion in genetics & development 2003
Tae Ho Shin Craig C Mello

Recent studies in Caenorhabditis elegans implicate PcG- and NuRD-like chromatin regulators in the establishment and maintenance of germline-soma distinctions. Somatic cells appear to utilize NuRD-related nucleosome-remodeling factors to overwrite germline-specific chromatin states that are specified through PcG-like activities. The germline, in turn, may rely on an asymmetrically inherited inhi...

Journal: :Cell Stem Cell 2012

Journal: :Nature Reports Stem Cells 2009

Journal: :Nature Reviews Genetics 2018

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