Pneumocystis canis is a potential cause of life-threatening interstitial fungal pneumonia in dogs. It is seen almost exclusively in two canine breeds, miniature Dachshunds and Cavalier King Charles Spaniels (CKCS). Historically, Australian veterinarianshadakey role in thedocumentation of this entity and its conspicuous breed associations. Affected Dachshunds and CKCS are likely to have an inher...

Pneumocystis pneumonia (PCP) has historically been one of the leading causes of disease among persons with AIDS. The introduction of highly active antiretroviral therapy in industrialized nations has brought about dramatic declines in the incidence of AIDS-associated complications, including PCP. In the adult population, the incidence of PCP has significantly decreased, but it remains among the...

The detection of Pneumocystis DNA in clinical specimens by using PCR assays is leading to important advances in Pneumocystis pneumonia (PcP) clinical diagnosis, therapy and epidemiology. Highly sensitive and specific PCR tools improved the clinical diagnosis of PcP allowing an accurate, early diagnosis of Pneumocystis infection, which should lead to a decreased duration from onset of symptoms t...

A diagnosis of PneumocysHs carinii pneumonia was made in seven patients by the technique of transbronchoscopic lung biopsy. In this technique, flexible forceps are inserted through a rigid broncbosrrope. No false wgathre re& were obtained, that is, no other cases of pneumocysHs pneumonia were discovered by any additional technique, including autopsy, among a group of 525 patients with difiuse p...

C.O., a female infant, had a birth weight of 6 lb. (2,720 g.). The parents were English and had one other normal child. She was admitted to hospital at the age of 3 days because of abdominal distension and vomiting. This settled without specific treatment. She went home but was readmitted two weeks later with similar symptoms together with loose stools. Intravenous fluids were required and E. c...

Pneumocystis carinii is an opportunistic fungal pathogen that causes life-threatening pneumonia in immunocompromised individuals. Infants appear to be particularly susceptible to infection with Pneumocystis. We have previously shown that there is a significant delay in clearance of the organisms from the lungs of neonatal mice compared to adults. Since alveolar macrophages are the effector cell...

Pneumocystis carinii is an opportunistic fungal pathogen that causes life-threatening pneumonia in immunocompromised individuals. Infants appear to be particularly susceptible to Pneumocystis pulmonary infections. We have previously demonstrated that there is approximately a 3-week delay in the clearance of Pneumocystis organisms from pup mouse lungs compared to that in adults. We have further ...

Pneumonia complicating pregnancy requires a prompt diagnosis and the institution of adequate supportive and antimicrobial therapy. In a patient with a classic presentation of pneumonia, the most likely pathogens are Streptococcus pneumoniae and Haemophilus influenzae. In a patient with an atypical presentation of pneumonia, Mycoplasma pneumoniae and Chlamydia pneumoniae are frequently encounter...