PURPOSE To identify myocilin (MYOC) and cytochrome P450, family 1, subfamily B, polypeptide 1 (CYP1B1) mutations in a Spanish population with different clinical forms of familial glaucoma or ocular hypertension (OHT). METHODS Index patients from 226 families participated in this study. Patients were diagnosed with familial glaucoma or OHT by complete ophthalmologic examination. Screening for ...

Objective: To characterize the efficacy of earlier versus later treatment in preventing primary open angle glaucoma (POAG) in individuals with ocular hypertension. Design: Randomized controlled clinical trial. Participants/Methods: 1636 individuals with elevated intraocular pressure between 24 and 32 mm Hg in one eye and 21 and 32 mm Hg in the fellow eye were randomly assigned to observation or...

Primary open-angle glaucoma (POAG) is a leading cause of blindness worldwide. The genetics of POAG are complex, and population-specific effects have been reported. Although many polymorphisms associated with POAG risk have been reported, few studies have analyzed their additive effects. We investigated, in a southern European Mediterranean population, the association between relevant POAG polym...

Systematic review of published population based surveys to examine the relationship between primary open angle glaucoma (POAG) prevalence and demographic factors. A literature search identified population-based studies with quantitative estimates of POAG prevalence (to October 2014). Multilevel binomial logistic regression of log-odds of POAG was used to examine the effect of age and gender amo...

Purpose/Aim: primary Open-angle glaucoma (POAG) is an asymptomatic, progressive optic neuropathy characterized by enlarging disc cupping and visual field loss. POAG a major cause of blindness degeneration the nerve usually associated with elevated intraocular pressure. Regarding fact that dyslipidemia has relationship some ophthalmic diseases such as cataract,it sounds same also exists POAG. Th...

Glaucoma is a primary cause of irreversible blindness worldwide, it kills the vision silently, having financial burden on society regarding therapy expenses and loss valuable hours day. Objective: To compare choroidal filling time grade status pattern optic nerve head (ONH) perfusion by fundus fluorescein angiography (FFA) in glaucoma patients Methods: Patients with various types were enrolled ...

AIM To describe the outcomes of bleb needling in primary glaucoma in an Asian tertiary eye centre over a 2y period. To compare the success rates between primary angle-closure glaucoma (PACG) and primary open angle glaucoma (POAG). Lastly, to identify factors associated with success of bleb needling. METHODS This was a retrospective review of 227 patients who underwent bleb needling between Ju...

PURPOSE This study was designed to evaluate the levels of Interleukin-6 (IL6) and Hepcidin prohormone (Hep) in the serum and aqueous humor of patients with primary open-angle glaucoma (POAG), as well as those with senile cataract as a control group. METHODS Levels of IL6 and Hep were measured by enzyme-linked immunosorbent assay (ELISA) methods in serum and aqueous humor aspirates taken from ...

PURPOSE To discover sequence alterations in the TIGR/MYOC gene associated with primary open-angle glaucoma (POAG) in Chinese subjects. METHODS Two hundred one unrelated Chinese patients with POAG and 291 unrelated individuals without glaucoma, aged 50 years or more, were screened for sequence alterations in the TIGR/MYOC gene by polymerase chain reaction, conformation sensitive gel electropho...

PURPOSE To study the association of apolipoprotein E (APOE) polymorphisms and primary open-angle glaucoma (POAG). METHODS After a systematic literature search, all relevant studies evaluating the association between APOE polymorphisms and POAG were included. All statistical tests were calculated with Stata 11.0. RESULTS Twelve independent studies on the APOE gene (1,971 cases, 1,756 control...