Drosophila neuroblasts are a model system for studying stem cell self-renewal and the establishment of cortical polarity. Larval neuroblasts generate a large apical self-renewing neuroblast, and a small basal cell that differentiates. We performed a genetic screen to identify regulators of neuroblast self-renewal, and identified a mutation in sgt1 (suppressor-of-G2-allele-of-skp1) that had fewe...

Epithelial cells are polarized along their apical-basal axis. Much of the cellular machinery that goes into establishing and maintaining epithelial cell polarity is evolutionarily conserved. Model organisms, including the fruit fly, Drosophila melanogaster, are thus particularly useful for the study of cell polarity. Work in Drosophila has identified several important components of the polarity...

Polarity shifting marked by various linguistic structures has been a challenge to automatic sentiment classification. In this paper, we propose a machine learning approach to incorporate polarity shifting information into a document-level sentiment classification system. First, a feature selection method is adopted to automatically generate the training data for a binary classifier on polarity ...

Numerical simulations of the interaction internal solitary waves (ISWs) opposite polarity are conducted by solving incompressible Euler equations under Boussinesq approximation. A double-pycnocline stratification is used. method to determine when ISWs both polarities exist also presented. The confirm previous work that same soliton-like; however, here it shown a fast ISW with as Korteweg–de Vri...

Apico-basal polarity is typical of cells present in differentiated epithelium while front-rear polarity develops in motile cells. In cancer development, the transition from epithelial to migratory polarity may be seen as the hallmark of cancer progression to an invasive and metastatic disease. Despite the morphological and functional dissimilarity, both epithelial and migratory polarity are con...

Changes in expression and localization of proteins that regulate cell and tissue polarity are frequently observed in carcinoma. However, the mechanisms by which changes in cell polarity proteins regulate carcinoma progression are not well understood. Here, we report that loss of polarity protein expression in epithelial cells primes them for cooperation with oncogenes or changes in tissue micro...

Reading text from computer screens is better when text is printed in dark letters on light background (positive polarity) than when it is printed in light letters on dark background (negative polarity). An experiment is presented that tests whether this positive polarity advantage is due to the fact that overall display luminance is typically higher for positive than for negative polarity displ...

In both Drosophila melanogaster and mammalian systems, epithelial structure and underlying cell polarity are essential for proper tissue morphogenesis and organ growth. Cell polarity interfaces with multiple cellular processes that are regulated by the phosphorylation status of large protein networks. To gain insight into the molecular mechanisms that coordinate cell polarity with tissue growth...