BACKGROUND Delivery of a high concentration of anticancer drugs specifically to cancer cells remains the biggest challenge for the treatment of multidrug-resistant cancer. Poloxamers and D-α-Tocopheryl polyethylene glycol 1000 succinate (TPGS) are known inhibitors of P-glycoprotein (P-gp). Mixed micelles prepared from Poloxamer 407 and TPGS may increase the therapeutic efficacy of the drug by d...

Aim: Poloxamer a block copolymer is well known for its thermoreversible property also has several other properties used in several formulations for its advantage over optimising the drug release from its formulation with a sol-gel transition property. Methods: Poloxamer exhibits in a sol state at less than room temperature and gets converted to a gel state at body temperature (37.2°C) thus modi...

Umifenovir is one of the most often prescribed antiviral medications for prevention and treatment COVID-19 other viral infections. Herein, a UPLC-MS/MS method developed through using ibrutinib as an internal standard (IS) quantifying umifenovir in plasma samples. Both IS were analytically separated on Acquity BEH C18 column with total run time only 2.5 min. At flow rate 0.3 mLmin−1, acetonitril...

The main objective of this work is to characterize the rheological behavior of poloxamer 407 solutions and gels in various shear flow fields.

The objectives of this study were to evaluate poloxamer as a slow release carrier for morphine (M) and potential tissue irritation after subcutaneous poloxamer-morphine (PM) injection in a rat model. Based on the result of a previous in vitro work, 25% poloxamer, with and without morphine, and saline were administered in 14 rats' flanks. Blood for morphine concentrations was automatically sampl...