It is evident that di and polyamines are intimately related to growth processes (1-3). Actively dividing mammalian cells contain higher levels of polyamines than slowly growing or quiscent cells (4,5). Polyamine levels rise In different malignancies ((3,7). On the other hand, activity of Diamine oxidase (DAO; EC 1.4.3.6) increases in human carcinomatous growths as well as in experimental neopla...

The need for antineoplastic compounds with novel mechanisms of ac tion is great. One such agent is the recently synthesized polyamine analogue /V'-ethyl-A'n-((cyclopropyl)methyl)-4,8-diazaundecane (CPENSpm). Expo sure of hormone-dependent and -independent human breast cancer cells to 0.1-10 UM CPENSpm led to both growth inhibition and induction of pro grammed cell death. Fragmentation of DNA to...

Recently, extensive researches have emphasized the fact that polyamine conjugates are becoming important in all biological and medicinal fields. In this review, we will focus our attention on natural polyamines highlight recent progress both fundamental mechanism studies interests development application for therapeutic use of derivatives.

In our search for new antibiotic adjuvants as a novel strategy to deal with the emergence of multi-drug resistant (MDR) bacteria, series succinylprimaquine-polyamine (SPQ-PA) conjugates and derivatives cationic amphiphilic nature have been prepared. Evaluation these primaquine intrinsic antimicrobial properties ability restore activity doxycycline identified two derivatives, SPQ-PA3-8-3 SPQ-PA3...

Polyamines are polycations that interact with negatively charged molecules such as DNA, RNA and proteins. They play multiple roles in cell growth, survival and proliferation. Changes in polyamine levels have been associated with aging and diseases. Their levels decline continuously with age and polyamine (spermidine or high-polyamine diet) supplementation increases life span in model organisms....

In a previous work, it was observed that the swarming of polyamine-deficient Proteus mirabilis (speB::sm) was severely inhibited on Luria-Bertani (LB) swarming plates (LBSw) (LB, 0.5% glucose, 0.5% agar), and it was clarified that extracellular putrescine was important as a signaling molecule for the induction of swarming in P. mirabilis. However, a polyamine-deficient strain (delta-speAB delta...

Polyamines naturally occur in all living beings and play an important role in the regulation of cell proliferation, differentiation, and functional stimulation of terminally differentiated cells. Our studies, using specific inhibitors of polyamine biosynthesis such as alpha-difluoromethylornithine and methylglyoxal-bis[guanylhydrazone] to prevent polyamine accumulation, have indicated that poly...

As an antiproliferative strategy, we are using bis(ethyl) derivatives of spermine to suppress polyamine biosynthetic enzyme activity and, thereby, deplete intracellular polyamine pools. Since certain of these analogues have recently been shown to potently increase spermidine/spermine-N1-acetyltransferase activity, we have investigated the relationship of this effect to growth inhibition and pol...

A great deal of experimental evidence connects induction of polyamine catabolism via spermidine/spermine N1-acetyltransferase (SSAT) to antiproliferative activity and apoptosis. Following our initial observation from gene expression profiling that platinum drugs induce SSAT, we undertook this present study to characterize platinum drug induction of SSAT and other polyamine catabolic enzymes and...