Oligodendrocyte (OL) differentiation and myelin development are complex events regulated by numerous signal transduction factors. Here, we report that phosphoinositide-3 kinase enhancer L (PIKE-L) is required for OL development and myelination. PIKE-L expression is up-regulated when oligodendrocyte progenitor cells commit to differentiation. Conversely, depleting phosphoinositide-3 kinase enhan...

In the present study, we show that four unusual cholesterol precursors, 5α-cholesta-8,14-dien-3β-ol, 4-methyl-5α-cholesta-8,24-dien-3β-ol (4-methylzymosterol), 4,4,14-trimethyl-5α-cholesta-8,24-dien-3β-ol (lanosterol), and 4,4-dimethyl-5α-cholesta-8,24-dien-3β-ol (4,4-dimethylzymosterol) are present in testes of the limpet Cellana grata, which is part of one of the most primitive gastropod fami...

Seven parguerane diterpenes: 15-bromo-2,7,19-triacetoxyparguer-9(11)-en-16-ol (1), 15-bromo-2,7,16,19-tetraacetoxyparguer-9(11)-ene (2), 15-bromo-2,19-diacetoxyparguer-9(11)-en-7,16-diol (3), 15-bromo-2,16,19-triacetoxyparguer-9(11)-en-7-ol (4), 15-bromo-2,16-diacetoxyparguer-9(11)-en-7-ol (5), 15-bromoparguer-9(11)-en-16-ol (6), 15-bromoparguer-7-en-16-ol (7), two polyether triterpenes: thyrsi...

The public reporting burden lor this collodion ol mlormalion is estimated lo overage 1 hour per response, including the time (or reviewing mslruclions, searching existing dala sources, gathering and maintaining the dala needed, fend completing and reviewing the colleclion ol mlormalion Send comments regarding this burden eslimate or any olhor aspect ol this collodion ol mlormalion, including su...

Steroid-8-ene isomerase that catalyzes isomerization of delta 8- to delta 7-sterols has been solubilized from rat liver microsomes with a mixture of two detergents, octylglucoside and sodium taurodeoxycholic acid. During a 40-fold enrichment of the solubilized enzyme, other enzymes of cholesterol biosynthesis, endogenous lipids, and electron carriers are removed. A comparison of properties of t...

Irradiation of rat skeletal muscles before increased loading has been shown to prevent compensatory hypertrophy for periods of up to 4 wk, possibly by preventing satellite cells from proliferating and providing new myonuclei. Recent work suggested that stem cell populations exist that might allow irradiated muscles to eventually hypertrophy over time. We report that irradiation essentially prev...

OBJECTIVE To analyze the frequency of unlicensed (UL) and off-label (OL) prescriptions in neonates admitted to the neonatal intensive care unit of a tertiary care hospital and to determine their association with patients' severity. METHODS Observational cohort study including drugs prescribed during hospitalization of neonates over a 6-week period between July and August 2011. The drugs were ...

Open lesson (OL), similar to the Japanese study in many aspects, is a professional development model regularly used schools Commonwealth of Independent States Countries. The purpose this was examine teachers’ and students’ attitudes beliefs about OL practices activities, using both quantitative qualitative methods. sample consisted 72 instructors 239 university students Kazakhstan. MANOVA resul...

Essential oil of Baru Cina leaves (Artemisia vulgaris L.) has been successfully isolated by hydrodistillation method using the Stahl apparatus. were for ± 6 hours to produce essential amount 0.39 % (v/b). The obtained from was characterized GC-MS spectroscopy. analysis results showed that there 29 compounds and main identified as many 14 compounds, such Alpha-Pinene (0.33%), 1,8-Cineol (1.96% )...