Isopropyl (IPLA), N-methyl-N-isopropyl (MIPLA), N-ethyl-N-isopropyl (EIPLA), and N,N-diisopropyl (DIPLA) lysergamides were evaluated for lysergic acid diethylamide (LSD)-like activity. In rats trained to discriminate 0.08 mg/kg LSD tartrate from saline, each of the subject compounds completely substituted, with an ED50 two to three times larger than that of LSD except for DIPLA, which had an ED...

In the title compound, C(24)H(25)NO(7)S, the sulfonyl-bound phenyl ring is approximately perpendicular to the indole ring system [dihedral angle = 87.72 (5)°]. The methyl group of one of the ester units is disordered over two positions with occupancies of 0.527 (13) and 0.473 (13). An intra-molecular C-H⋯O hydrogen bond is observed. In the crystal structure, mol-ecules are linked into a ribbon ...

Phthalic acid esters (phthalates) are used as plasticizers in numerous consumer products, commodities, and building materials. Consequently, phthalates are found in human residential and occupational environments in high concentrations, both in air and in dust. Phthalates are also ubiquitous food and environmental contaminants. An increasing number of studies sampling human urine reveal the ubi...

Most natural odors are mixtures and often elicit percepts distinct from those elicited by their constituents. This emergence of a unique odor quality has long been attributed to central processing. Here we show that sophisticated integration of olfactory information begins in olfactory receptor neurons (ORNs) in Drosophila. Odor mixtures are encoded in the temporal dynamics as well as in the ma...

In the title complex, [Mn(2)(C(10)H(16)O(4))(C(12)H(8)N(2))(4)(H(2)O)(2)](NO(3))(2)·C(10)H(18)O(4)·2H(2)O, the asymmetric unit contains one-half of the centrosymmetric dinuclear complex cation, one uncoordinated water molecule, one-half of a free sebaic acid (decanedioic acid) molecule that is also completed by inversion symmetry, and one disordered nitrate anion [occupancy ratio 0.454 (4):0.54...

Calix[4]-bis-2,3-naphtho-crown-6 can be used to discriminate between methylammonium and other organic ammonium ions. An electrode based on this ionophore, potassium tetrakis(p-chlorophenyl)borate (20 mol% relative to the ionophore) as an ionic additive and bis(2-ethylhexyl) sebacate as a solvent mediator in a poly(vinyl chloride) membrane matrix, displayed higher selectivity for methylammonium ...

Riboflavin was encapsulated in pea protein microparticles crosslinked by transglutaminase and the release properties of this system studied simulated gastric (pH = 1.2) intestinal 7.4) fluids. The were obtained from a water-in-oil emulsion subsequent enzymatic gelation. In presence polyglycerol polyricinoleate as hydrophobic surfactant, magnetic agitation preferred to high-speed homogenization ...

We synthesized and evaluated biodegradable and elastomeric polyesters (poly(glycerol sebacate) (PGS)) using polycondensation between glycerol and sebacic acid to form a cross-linked network structure without using exogenous catalysts. Synthesized materials possess good mechanical properties, elasticity, and surface erosion biodegradation behavior. The tensile strength of the PGS was as high as ...

Poly(glycerol sebacate) (PGS) has increasingly become a desirable biomaterial due to its elastic mechanical properties, biodegradability, and biocompatibility. Here, we report microfibrous core−shell mats of polycaprolactone (PCL)−PGS prepared using wet−wet coaxial electrospinning. The anticoagulant heparin was immobilized onto the surface of these electrospun fiber mats, and they were evaluate...