BACKGROUND AND AIMS We investigated oral delivery of transforming growth factor beta 1 [TGFβ]- and all-trans retinoic acid [ATRA]-loaded microspheres as therapy for gut inflammation in murine models of inflammatory bowel disease [IBD]. METHODS ATRA and TGFβ were separately encapsulated in poly [lactic-co-glycolic] acid or polylactic acid microspheres [respectively]. TGFβ was encapsulated usin...

In this primary study, thin polylactic-co-glycolic acid (PLGA) film loaded with geniposide was first prepared and demonstrated on both physical and pharmacological aspects for its potential application on drug-eluting vascular stents. Physical parameters of geniposide-loaded thin film, such as crystal structure, molecular spectral characteristics, and release behavior in the whole process were ...

Abstract Background The integration of 3D printing technology in hospitals is evolving toward production models such as point-of-care manufacturing. This study aims to present the results a manufacturing university hospital. Methods Observational, descriptive, retrospective, and monocentric 907 instances from November 2015 March 2020. Variables product type, utility, time, or materials were ana...

Introduction Biodegradable stents have the potential to avoid long-term complications of conventional stents such as in-stent restenosis and late stent thrombosis, and could allow for a restoration of vasomotion and vessel growth which makes them suitable for e.g. paediatric applications [1]. To investigate the mechanics of this new type of stent via finite element simulations, we developed a n...

An endogenous depolymerization model based on uniform weight distribution is introduced. The time dependent model with temporal dependent degradation rate is reduced to a time independent model. The previously developed techniques were applied to an inverse problem to determine the degradation rate. The transition of weight distribution was simulated by solving an initial value problem. Those t...

Polylactic acid (PLA) was successfully covalently grafted onto multi-walled carbon nanotubes (MWCNT) by microwave-assisted polymerization of lactide monomers. The final products MWCNT-g-PLA were characterized with Fourier-transform IR (FTIR), Raman spectroscopy, thermogravimetric analyses (TGA) and transmission electron microscopy (TEM). The results indicated PLA chain was covalently attached t...

Protein-coated resorbable synthetic polymeric nanofibrous membranes are promising for the fabrication of advanced skin substitutes. We fabricated electrospun polylactic acid and poly(lactide-co-glycolic acid) nanofibrous membranes and coated them with fibrin or collagen I. Fibronectin was attached to a fibrin or collagen nanocoating, in order further to enhance the cell adhesion and spreading. ...

Dichloromethane (DCM) and acetonitrile (ACN) are the most commonly used solvents for polylactic acid (PLA) or poly(lactic-co-glycolic acid) (PLGA). In order to select a suitable solvent system for the preparation of PLGA microspheres containing tumor necrosis factor-alpha (TNF-a), the stability of TNF-a when mixed with DCM and ACN under various phase conditions was investigated. When the TNF-a ...

The association of bioactive molecules, such as vascular endothelial growth factor (VEGF), with nanofibers facilitates their controlled release, which could contribute to cellular migration and differentiation in tissue regeneration. In this research, the influence of their incorporation on a polylactic-co-glycolic acid (PLGA) scaffold produced by electrospinning on cell adhesion and viability ...

A microvascular network is critical for the survival and function of most tissues. We have investigated the potential of neural progenitor cells to augment the formation and stabilization of microvascular networks in a previously uncharacterized three-dimensional macroporous hydrogel and the ability of this engineered system to develop a functional microcirculation in vivo. The hydrogel is synt...