conclusions the obtained results confirm some previous studies regardinga gender specific association of maoa gene with the bipolar disorder. results significant associations were observed regarding maoa-ca (p = 0.016) and maoa-vntr (p = 0.004) polymorphisms in the bipolar females. there was no association between maoa-rflp and bipolar disorder. patients and methods this study is a case-control...

the aim of the present study was to assess the frequencies of angiotensin i-converting enzyme (ace; omim: 106180) and methylenetetrahydrofolate reductase (mthfr; omim: 607093) polymorphisms in the algerian population to further facilitate investigations on possible associations with various pathologies. the study was carried out on 146 apparently healthy individuals (65 males, 81 females) who w...

background the association between tumor necrosis factor-alpha (tnf-α) (-308 g/a) gene polymorphisms and level of tissue destruction and periodontal disease progression is not proved. objectives the present study investigated the stereological parameters of interdental papilla in chronic periodontitis (cp) patients with tnf-α (-308 g/a) gene polymorphisms. materials and methods sixty gingiva sa...

Inflammatory bowel disease (IBD) applies to two main forms of chronic relapsing inflammatory intestinal disorders: Crohn's (CD), Ulcerative colitis (UC). CD requires an irregular immune reaction that induces intense inflammation. The cause is not yet fully known; previous research, however, indicated inflammation the intestines elevated or continues due inappropriate responses associations betw...

This article shows the results of studies in course which a comparative aspect LEP polymorphism was studied subpopulations Holstein dairy cattle cows with fatty hepatosis and healthy animals. is first time such are being conducted. In this case, hepothesis about relationship genetic markers, particular leptin gene, risk developing progression liver disease model when determining frequency occur...

The review presents modern studies the effect of genetic polymorphisms on efficienty and safety therapy with new oral anticoagulants. Hepatic carboxylesterase encoded by CES1 gene P-glycoprotein ABCB1 affect dabigatran pharmacokinetics. role glucuronidation enzymes (UGT2B15, UGT1A9, UGT2B7) involved in active metabolism is poorly understood. An increase peak apixaban concentration was noted pat...

background: hemophilia b is an x-linked recessive coagulation disorder caused by factor ix deficiency.  analysis of factor ix gene polymorphisms is considered the best approach for prenatal diagnosis and carrier detection of hemophilia b where the identification of gene mutation is not easily possible.   objective: to study the frequency of three factor ix-linked restriction fragment length pol...

objective(s) deregulation of the immune system through allied factors and cytokine responses are thought to be important contributors to the pathogenesis of asthma. vitamin d3 and its nuclear receptor appear to be factors that maybe involved in regulating immune responses during the progression of asthma. the aim of this study was to investigate the association between polymorphisms in intron 8...

in this research, samples were collected from three iranian native dogs and three wolves. whole-genome sequencing for each individual was performed using next-generation sequencing technology. all short reads were aligned to the reference genome using bwa tool. single-nucleotide polymorphisms (snps) and small insertions and deletions (indels) were detected using the genome analysis toolkit (gat...

The primary aim of this study was to investigate the status of RANKL6-7 gene polymorphism in patients with chronic (mild, moderate, severe) and aggressive periodontitis as well as healthy controls. We examined80 patients for the RANKL6-7 polymorphisms (rs1054016 and rs9567000). Polymorphism was determinedby polymerase chain reaction (PCR) followed by direct sequencing. No statistica...