GOAL Inappropriate prescribing of a multiple therapeutic agents to patients with chronic conditions is very common in everyday practice. Adverse drug reactions (ADRs) are still considered as one of the main problems of drug therapy. We investigated idiosyncratic symptoms and signs of adverse drug reactions (ADRs) of the most frequent used combination of drugs among hospitalized patients prescri...

conclusions: the current review is aimed at analyzing and managing various clinical aspects of hypothyroidism in hospitalized elderly, and critically ill geriatric patients. context: articles in various international and national bibliographic indices were extensively searched with an emphasis on thyroid and hypothyroid disorders, hypothyroidism in elderly hospitalized patients, hypothyroidism ...

Abstract Background Polymedicated older patients are at greater risk of suffering from adverse events. For this reason, the detection both inappropriate polypharmacy and polypharmacy-associated Drug-Related Problems (DRPs) essential to improve health wellbeing adults reduce healthcare costs. This work aims explore professionals’ perceptions opinions about handling medicines by polymedicated adu...

BACKGROUND Antipsychotic monotherapy is recognized as the treatment of choice for patients with schizophrenia. Simultaneous treatment with multiple antipsychotics (polypharmacy) is suggested by some expert consensus guidelines as the last resort after exhausting monotherapy alternatives. This study assessed the annual rate and duration of antipsychotic monotherapy and its inverse, antipsychotic...

BACKGROUND Multimorbidity is increasing in aging populations with a corresponding increase in polypharmacy as well as inappropriate prescribing. Depending on definitions, 25-50 % of patients aged 75 years or older are exposed to at least five drugs. Evidence is increasing that polypharmacy, even when guidelines advise the prescribing of each drug individually, can potentially cause more harm th...

BACKGROUND A lack of gold standard treatment for autism spectrum disorders (ASD), no clear ASD management guidelines, and lack of evidence-based pharmacological interventions other than aripiprazole and risperidone elevate the risk of off-label prescribing and adverse effects among individuals with ASD, more so among adults. OBJECTIVE The aim of this study was to identify and compare the type...

The elderly use drugs more commonly than younger persons. Many studies about drug use have concentrated on institutionalized elders. Knowledge of drug use by the oldest old, aged 85 years or over, is scant. Psychotropics are among the drugs most commonly used by the elderly. Psychotropics have many adverse effects, such as balance impairment, sedation, reduced cognition, depression, and extrapy...

Objective Given the complex nature and frequent comorbidities of bipolar disorder (BD), polypharmacy is often used to achieve and maintain remission. In clinical practice, this is frequently the rule rather than the exception. Although research on BD uncommonly involves controlled clinical studies for combination therapies, clinicians nonetheless utilize polypharmacy as the best clinical treatm...